Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder
The high rates of chronicity and recurrences account for the limited efficacy of current antidepressants, conceived based on the current neurobiological hypotheses, in reaching the full clinical and functional remission of major depressed (MDD) patients. We aimed to analyze the role of pro-inflammat...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/16/5615 |
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| author | Ileana Enatescu Raluka Kalinovic Catalina Giurgi-Oncu Vladimir Poroch Ioan Sorin Stratulat Gabriela Vlad Oana Neda-Stepan Mihaela Simu Ion Papava Roxana Oancea Raul Patrascu Virgil Radu Enatescu |
| author_facet | Ileana Enatescu Raluka Kalinovic Catalina Giurgi-Oncu Vladimir Poroch Ioan Sorin Stratulat Gabriela Vlad Oana Neda-Stepan Mihaela Simu Ion Papava Roxana Oancea Raul Patrascu Virgil Radu Enatescu |
| author_sort | Ileana Enatescu |
| collection | DOAJ |
| description | The high rates of chronicity and recurrences account for the limited efficacy of current antidepressants, conceived based on the current neurobiological hypotheses, in reaching the full clinical and functional remission of major depressed (MDD) patients. We aimed to analyze the role of pro-inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), respectively, and type D personality (TDP) on the depressive symptoms measured by the 17-item Hamilton Depression Rating Scale (HAM-D). The processed data are part of a prospective 8-weeks follow-up study conducted in 50 subjects with MDD referred to ‘Eduard Pamfil’ Psychiatric Clinic Timisoara. The presence of elevated pro-inflammatory markers in MDD patients with TDP has been significantly associated with higher somatic anxiety (<i>p</i> = 0.005) and somatic symptoms-general (<i>p</i> = 0.016) mean rank scores compared to their counterparts without significant inflammation. The combination of increased CRP and IL-6 levels were significantly correlated with higher impaired insight (<i>p</i> = 0.026) mean rank scores, additionally. The presence of a significant level of IL-6 has shown a significant effect of size (<i>p</i> = 0.023) on the severity of major depression at baseline. On the contrary, type D personality has not influenced the severity of depressive symptoms (<i>p</i> > 0.05). Inflammatory markers significantly impact the clinical profiles and symptoms severity of MDD patients. |
| first_indexed | 2024-03-10T17:29:41Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T17:29:41Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-67556b2381db49269a8e1a37f449ec1e2023-11-20T10:03:28ZengMDPI AGApplied Sciences2076-34172020-08-011016561510.3390/app10165615Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive DisorderIleana Enatescu0Raluka Kalinovic1Catalina Giurgi-Oncu2Vladimir Poroch3Ioan Sorin Stratulat4Gabriela Vlad5Oana Neda-Stepan6Mihaela Simu7Ion Papava8Roxana Oancea9Raul Patrascu10Virgil Radu Enatescu11Department of Obstetrics and Gynecology-Discipline of Childcare and Neonatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania“Pius Brinzeu” Emergency County Hospital-Psychiatric Clinic, 156 Liviu Rebreanu Blvd., 300723 Timisoara, Romania“Pius Brinzeu” Emergency County Hospital-Psychiatric Clinic, 156 Liviu Rebreanu Blvd., 300723 Timisoara, Romania2nd Department of Internal Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania2nd Department of Internal Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania“Pius Brinzeu” Emergency County Hospital-Psychiatric Clinic, 156 Liviu Rebreanu Blvd., 300723 Timisoara, Romania“Pius Brinzeu” Emergency County Hospital-Psychiatric Clinic, 156 Liviu Rebreanu Blvd., 300723 Timisoara, RomaniaDepartment of Neuroscience, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania“Pius Brinzeu” Emergency County Hospital-Psychiatric Clinic, 156 Liviu Rebreanu Blvd., 300723 Timisoara, RomaniaDiscipline of Preventive Dentistry, Community and Oral Health, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, RomaniaDepartment of Functional Sciences—Physiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania“Pius Brinzeu” Emergency County Hospital-Psychiatric Clinic, 156 Liviu Rebreanu Blvd., 300723 Timisoara, RomaniaThe high rates of chronicity and recurrences account for the limited efficacy of current antidepressants, conceived based on the current neurobiological hypotheses, in reaching the full clinical and functional remission of major depressed (MDD) patients. We aimed to analyze the role of pro-inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), respectively, and type D personality (TDP) on the depressive symptoms measured by the 17-item Hamilton Depression Rating Scale (HAM-D). The processed data are part of a prospective 8-weeks follow-up study conducted in 50 subjects with MDD referred to ‘Eduard Pamfil’ Psychiatric Clinic Timisoara. The presence of elevated pro-inflammatory markers in MDD patients with TDP has been significantly associated with higher somatic anxiety (<i>p</i> = 0.005) and somatic symptoms-general (<i>p</i> = 0.016) mean rank scores compared to their counterparts without significant inflammation. The combination of increased CRP and IL-6 levels were significantly correlated with higher impaired insight (<i>p</i> = 0.026) mean rank scores, additionally. The presence of a significant level of IL-6 has shown a significant effect of size (<i>p</i> = 0.023) on the severity of major depression at baseline. On the contrary, type D personality has not influenced the severity of depressive symptoms (<i>p</i> > 0.05). Inflammatory markers significantly impact the clinical profiles and symptoms severity of MDD patients.https://www.mdpi.com/2076-3417/10/16/5615depressioninflammatory markerschronic medical comorbiditypsychopathology |
| spellingShingle | Ileana Enatescu Raluka Kalinovic Catalina Giurgi-Oncu Vladimir Poroch Ioan Sorin Stratulat Gabriela Vlad Oana Neda-Stepan Mihaela Simu Ion Papava Roxana Oancea Raul Patrascu Virgil Radu Enatescu Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder Applied Sciences depression inflammatory markers chronic medical comorbidity psychopathology |
| title | Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder |
| title_full | Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder |
| title_fullStr | Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder |
| title_full_unstemmed | Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder |
| title_short | Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder |
| title_sort | study on the role of inflammatory markers and type d personality on symptom profiles and severity in patients with major depressive disorder |
| topic | depression inflammatory markers chronic medical comorbidity psychopathology |
| url | https://www.mdpi.com/2076-3417/10/16/5615 |
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