Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA Vaccination
Introduction: Accumulating evidence has disclosed that IgA nephropathy (IgAN) could present shortly after the second dose of COVID-19 mRNA vaccine. However, the undying mechanism remains unclear and we aimed to investigate the potential molecular mechanisms. Methods: We downloaded gene expression da...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-02-01
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| Series: | Kidney & Blood Pressure Research |
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| Online Access: | https://beta.karger.com/Article/FullText/535626 |
| _version_ | 1797291567310962688 |
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| author | Luoyi Wang Zhaomin Mao Lirong Zhang Fengmin Shao |
| author_facet | Luoyi Wang Zhaomin Mao Lirong Zhang Fengmin Shao |
| author_sort | Luoyi Wang |
| collection | DOAJ |
| description | Introduction: Accumulating evidence has disclosed that IgA nephropathy (IgAN) could present shortly after the second dose of COVID-19 mRNA vaccine. However, the undying mechanism remains unclear and we aimed to investigate the potential molecular mechanisms. Methods: We downloaded gene expression datasets of COVID-19 mRNA vaccination (GSE201535) and IgAN (GSE104948). Weighted Gene Co-Expression Network Analysis (WGCNA) was performed to identify co-expression modules related to the second dose of COVID-19 mRNA vaccination and IgAN. Differentially expressed genes (DEGs) were screened, and a transcription factor (TF)-miRNA regulatory network and protein-drug interaction were constructed for the shared genes. Results: WGCNA identified one module associated with the second dose of COVID-19 mRNA vaccine and four modules associated with IgAN. Gene ontology (GO) analyses revealed enrichment of cell cycle-related processes for the COVID-19 mRNA vaccine hub genes and immune effector processes for the IgAN hub genes. We identified 74 DEGs for the second dose of COVID-19 mRNA vaccine and 574 DEGs for IgAN. Intersection analysis with COVID-19 vaccine-related genes led to the identification of two shared genes, TOP2A and CEP55. The TF-miRNA network analysis showed that hsa-miR-144 and ATF1 might regulate the shared hub genes. Conclusions: This study provides insights into the common pathogenesis of COVID-19 mRNA vaccination and IgAN. The identified pivotal genes may offer new directions for further mechanistic studies of IgAN secondary to COVID-19 mRNA vaccination. |
| first_indexed | 2024-03-07T19:39:26Z |
| format | Article |
| id | doaj.art-6758bfce11924a80a23594ea64fc3899 |
| institution | Directory Open Access Journal |
| issn | 1423-0143 |
| language | English |
| last_indexed | 2024-03-07T19:39:26Z |
| publishDate | 2024-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-6758bfce11924a80a23594ea64fc38992024-02-29T07:06:18ZengKarger PublishersKidney & Blood Pressure Research1423-01432024-02-0149114415410.1159/000535626535626Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA VaccinationLuoyi Wang0Zhaomin Mao1Lirong Zhang2Fengmin Shao3Department of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Clinical Laboratory, Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou University, Zhengzhou, ChinaDepartment of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Zhengzhou, ChinaIntroduction: Accumulating evidence has disclosed that IgA nephropathy (IgAN) could present shortly after the second dose of COVID-19 mRNA vaccine. However, the undying mechanism remains unclear and we aimed to investigate the potential molecular mechanisms. Methods: We downloaded gene expression datasets of COVID-19 mRNA vaccination (GSE201535) and IgAN (GSE104948). Weighted Gene Co-Expression Network Analysis (WGCNA) was performed to identify co-expression modules related to the second dose of COVID-19 mRNA vaccination and IgAN. Differentially expressed genes (DEGs) were screened, and a transcription factor (TF)-miRNA regulatory network and protein-drug interaction were constructed for the shared genes. Results: WGCNA identified one module associated with the second dose of COVID-19 mRNA vaccine and four modules associated with IgAN. Gene ontology (GO) analyses revealed enrichment of cell cycle-related processes for the COVID-19 mRNA vaccine hub genes and immune effector processes for the IgAN hub genes. We identified 74 DEGs for the second dose of COVID-19 mRNA vaccine and 574 DEGs for IgAN. Intersection analysis with COVID-19 vaccine-related genes led to the identification of two shared genes, TOP2A and CEP55. The TF-miRNA network analysis showed that hsa-miR-144 and ATF1 might regulate the shared hub genes. Conclusions: This study provides insights into the common pathogenesis of COVID-19 mRNA vaccination and IgAN. The identified pivotal genes may offer new directions for further mechanistic studies of IgAN secondary to COVID-19 mRNA vaccination.https://beta.karger.com/Article/FullText/535626covid-19vaccineiga nephropathytop2acep55 |
| spellingShingle | Luoyi Wang Zhaomin Mao Lirong Zhang Fengmin Shao Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA Vaccination Kidney & Blood Pressure Research covid-19 vaccine iga nephropathy top2a cep55 |
| title | Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA Vaccination |
| title_full | Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA Vaccination |
| title_fullStr | Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA Vaccination |
| title_full_unstemmed | Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA Vaccination |
| title_short | Molecular Pathogenic Mechanisms of IgA Nephropathy Secondary to COVID-19 mRNA Vaccination |
| title_sort | molecular pathogenic mechanisms of iga nephropathy secondary to covid 19 mrna vaccination |
| topic | covid-19 vaccine iga nephropathy top2a cep55 |
| url | https://beta.karger.com/Article/FullText/535626 |
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