A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan
Purpose: Several studies have shown that polypharmacy is the main cause of drug interactions, and the prevalence and the level of the severity varied with the duration of stay in the hospital, sex and race of the patients. The aims of this investigation were to identify the drug-drug interactions in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pediatric Reports |
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| Online Access: | https://www.mdpi.com/2036-7503/14/2/38 |
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| author | Hafiz Awais Nawaz Tahir Mehmood Khan Qendeel Adil Khang Wen Goh Long Chiau Ming Ali Qais Blebil Kah Seng Lee Jagjit Singh Dhaliwal |
| author_facet | Hafiz Awais Nawaz Tahir Mehmood Khan Qendeel Adil Khang Wen Goh Long Chiau Ming Ali Qais Blebil Kah Seng Lee Jagjit Singh Dhaliwal |
| author_sort | Hafiz Awais Nawaz |
| collection | DOAJ |
| description | Purpose: Several studies have shown that polypharmacy is the main cause of drug interactions, and the prevalence and the level of the severity varied with the duration of stay in the hospital, sex and race of the patients. The aims of this investigation were to identify the drug-drug interactions in hospitalized pediatric patients associated with polypharmacy, and to categorize the drug interactions in pharmacokinetic or pharmacodynamic interactions according to their level of severity. Methods: A cross-sectional, prospective analytical study was performed at a pediatric tertiary care hospital in Lahore, Pakistan for the duration of 4 months, which included prescription orders for 300 patients. Data were collected from patient medical files about previous and current medication history. Drug interactions were analyzed using interaction checker on Medscape and categorized according to the severity levels. Results: Out of 300 patients, the occurrence of drug interactions was found in 157 (52.3%) patients, while in 143 (47.7%), no interaction was found. Among these interactions, 50.7% were pharmacodynamic interactions, and 49.30% were pharmacokinetic interactions. Eighty-one percent of prescription orders with drug interactions contained more than three drugs, and 11.9% of interactions were severe. The majority of interactions were of amikacin-vancomycin, piroxicam-captopril and captopril-ciprofloxacin. Conclusion: Most of the interactions were moderate among patients with multiple drug prescriptions. The drug interactions can be minimized by providing special patient monitoring and adequate management with prior knowledge of these drug interaction. |
| first_indexed | 2024-03-09T22:47:23Z |
| format | Article |
| id | doaj.art-675936d64dad4b97ae295e1933aa7a56 |
| institution | Directory Open Access Journal |
| issn | 2036-7503 |
| language | English |
| last_indexed | 2024-03-09T22:47:23Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-675936d64dad4b97ae295e1933aa7a562023-11-23T18:26:14ZengMDPI AGPediatric Reports2036-75032022-06-0114231231910.3390/pediatric14020038A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, PakistanHafiz Awais Nawaz0Tahir Mehmood Khan1Qendeel Adil2Khang Wen Goh3Long Chiau Ming4Ali Qais Blebil5Kah Seng Lee6Jagjit Singh Dhaliwal7Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore 54000, PakistanInstitute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore 54000, PakistanInstitute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore 54000, PakistanFaculty of Data Science and Information Technology, INTI International University, Nilai 71800, MalaysiaPAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Gadong BE1410, BruneiSchool of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaFaculty of Pharmacy, University of Cyberjaya, Cyberjaya 63000, MalaysiaPAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Gadong BE1410, BruneiPurpose: Several studies have shown that polypharmacy is the main cause of drug interactions, and the prevalence and the level of the severity varied with the duration of stay in the hospital, sex and race of the patients. The aims of this investigation were to identify the drug-drug interactions in hospitalized pediatric patients associated with polypharmacy, and to categorize the drug interactions in pharmacokinetic or pharmacodynamic interactions according to their level of severity. Methods: A cross-sectional, prospective analytical study was performed at a pediatric tertiary care hospital in Lahore, Pakistan for the duration of 4 months, which included prescription orders for 300 patients. Data were collected from patient medical files about previous and current medication history. Drug interactions were analyzed using interaction checker on Medscape and categorized according to the severity levels. Results: Out of 300 patients, the occurrence of drug interactions was found in 157 (52.3%) patients, while in 143 (47.7%), no interaction was found. Among these interactions, 50.7% were pharmacodynamic interactions, and 49.30% were pharmacokinetic interactions. Eighty-one percent of prescription orders with drug interactions contained more than three drugs, and 11.9% of interactions were severe. The majority of interactions were of amikacin-vancomycin, piroxicam-captopril and captopril-ciprofloxacin. Conclusion: Most of the interactions were moderate among patients with multiple drug prescriptions. The drug interactions can be minimized by providing special patient monitoring and adequate management with prior knowledge of these drug interaction.https://www.mdpi.com/2036-7503/14/2/38drug safetydrug-related problemsdrug-drug interactionclinical pharmacy |
| spellingShingle | Hafiz Awais Nawaz Tahir Mehmood Khan Qendeel Adil Khang Wen Goh Long Chiau Ming Ali Qais Blebil Kah Seng Lee Jagjit Singh Dhaliwal A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan Pediatric Reports drug safety drug-related problems drug-drug interaction clinical pharmacy |
| title | A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan |
| title_full | A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan |
| title_fullStr | A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan |
| title_full_unstemmed | A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan |
| title_short | A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan |
| title_sort | prospective study of medication surveillance of a pediatric tertiary care hospital in lahore pakistan |
| topic | drug safety drug-related problems drug-drug interaction clinical pharmacy |
| url | https://www.mdpi.com/2036-7503/14/2/38 |
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