Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
Abstract Background To evaluate the surgical safety in myasthenia gravis (MG) patients aged 65 and over. Methods A total of 564 patients with MG who underwent surgery in the Department of Thoracic Surgery of Beijing Hospital from November 2011 to March 2022 were included in the study and divided int...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14799 |
| _version_ | 1811154195212926976 |
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| author | Peng Jiao Fanjuan Wu Jiangyu Wu Yaoguang Sun Wenxin Tian Hanbo Yu Chuan Huang Donghang Li Qingjun Wu Chao Ma Hongfeng Tong |
| author_facet | Peng Jiao Fanjuan Wu Jiangyu Wu Yaoguang Sun Wenxin Tian Hanbo Yu Chuan Huang Donghang Li Qingjun Wu Chao Ma Hongfeng Tong |
| author_sort | Peng Jiao |
| collection | DOAJ |
| description | Abstract Background To evaluate the surgical safety in myasthenia gravis (MG) patients aged 65 and over. Methods A total of 564 patients with MG who underwent surgery in the Department of Thoracic Surgery of Beijing Hospital from November 2011 to March 2022 were included in the study and divided into two groups taking the age of 65 as the boundary. Perioperative data of patients were recorded and statistically analyzed. Results Compared with young patients, FEV1, FEV1% and MVV in lung function of elderly MG patients were worse (p < 0.001, p < 0.001, p = 0.002). Postoperative drainage time was longer (p < 0.001), combined with more drainage volume (p = 0.002). The American Society of Anesthesiologists (ASA) score of elderly MG patients was higher (p < 0.001). Complications were more likely to occur (p = 0.008) after surgery and Clavien‐Dindo classification (CDC) of postoperative complications was also higher (p = 0.003). Meanwhile, postoperative myasthenic crisis (POMC) was more likely to occur (p = 0.038). Logistic regression showed that lower DLCO% (p = 0.049) was an independent risk factor for postoperative complications. Conclusions Surgical indications should be considered in each elderly MG patient on an individual basis. Moreover, most elderly MG patients safely survive the perioperative period and benefit from surgery through individualized consideration. |
| first_indexed | 2024-04-10T04:11:42Z |
| format | Article |
| id | doaj.art-67593f0574f1457397c18e255bc4066a |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-10T04:11:42Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-67593f0574f1457397c18e255bc4066a2023-03-13T02:00:47ZengWileyThoracic Cancer1759-77061759-77142023-03-0114871772310.1111/1759-7714.14799Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and overPeng Jiao0Fanjuan Wu1Jiangyu Wu2Yaoguang Sun3Wenxin Tian4Hanbo Yu5Chuan Huang6Donghang Li7Qingjun Wu8Chao Ma9Hongfeng Tong10Department of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of medicine Peking University Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Thoracic Surgery Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing ChinaAbstract Background To evaluate the surgical safety in myasthenia gravis (MG) patients aged 65 and over. Methods A total of 564 patients with MG who underwent surgery in the Department of Thoracic Surgery of Beijing Hospital from November 2011 to March 2022 were included in the study and divided into two groups taking the age of 65 as the boundary. Perioperative data of patients were recorded and statistically analyzed. Results Compared with young patients, FEV1, FEV1% and MVV in lung function of elderly MG patients were worse (p < 0.001, p < 0.001, p = 0.002). Postoperative drainage time was longer (p < 0.001), combined with more drainage volume (p = 0.002). The American Society of Anesthesiologists (ASA) score of elderly MG patients was higher (p < 0.001). Complications were more likely to occur (p = 0.008) after surgery and Clavien‐Dindo classification (CDC) of postoperative complications was also higher (p = 0.003). Meanwhile, postoperative myasthenic crisis (POMC) was more likely to occur (p = 0.038). Logistic regression showed that lower DLCO% (p = 0.049) was an independent risk factor for postoperative complications. Conclusions Surgical indications should be considered in each elderly MG patient on an individual basis. Moreover, most elderly MG patients safely survive the perioperative period and benefit from surgery through individualized consideration.https://doi.org/10.1111/1759-7714.14799Clavien Dindo classificationgeriatricsmyasthenia gravisthymectomy |
| spellingShingle | Peng Jiao Fanjuan Wu Jiangyu Wu Yaoguang Sun Wenxin Tian Hanbo Yu Chuan Huang Donghang Li Qingjun Wu Chao Ma Hongfeng Tong Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over Thoracic Cancer Clavien Dindo classification geriatrics myasthenia gravis thymectomy |
| title | Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over |
| title_full | Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over |
| title_fullStr | Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over |
| title_full_unstemmed | Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over |
| title_short | Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over |
| title_sort | surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over |
| topic | Clavien Dindo classification geriatrics myasthenia gravis thymectomy |
| url | https://doi.org/10.1111/1759-7714.14799 |
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