Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disr...

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Bibliographic Details
Main Authors: Stephane Dissel, Markus Klose, Jeff Donlea, Lijuan Cao, Denis English, Raphaelle Winsky-Sommerer, Bruno van Swinderen, Paul J. Shaw
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Neurobiology of Sleep and Circadian Rhythms
Online Access:http://www.sciencedirect.com/science/article/pii/S2451994416300153

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