FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction
A test-retest study of FreeSurfer derived cortical thickness, cortical surface area, and cortical volume, as well as quantitative R1 relaxometry assessed on the midpoint of the cortex, was performed on a cohort of pediatric subjects (6-12 years old) scanned without sedation using SNARE-MPnRAGE (self...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921007217 |
| _version_ | 1818601709808648192 |
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| author | Steven Kecskemeti Abigail Freeman Brittany G Travers Andrew L Alexander |
| author_facet | Steven Kecskemeti Abigail Freeman Brittany G Travers Andrew L Alexander |
| author_sort | Steven Kecskemeti |
| collection | DOAJ |
| description | A test-retest study of FreeSurfer derived cortical thickness, cortical surface area, and cortical volume, as well as quantitative R1 relaxometry assessed on the midpoint of the cortex, was performed on a cohort of pediatric subjects (6-12 years old) scanned without sedation using SNARE-MPnRAGE (self navigated retrospective motion corrected magnetization prepared with n rapid gradient echoes) imaging. Reliability was assessed with coefficients of variation (CoVs) and intraclass correlation coefficients (ICCs) and statistical tests were used to determine differences with and without SNARE motion correction. Comparison of the test-retest measures of SNARE-MPnRAGE with prospectively motion corrected PROMO MPRAGE were also performed. When SNARE motion correction was used all parameters had statistically significant improvements and demonstrated high reliability. Reliability varied depending on parameter, region, and measurement type (vertex or region of interest). For mean thickness/surface area/volume/mean R1 across the regions of FreeSurfer's DK Atlas, the mean CoVs (% x100) were (1.2/1.6/1.9/0.9) and the mean ICCs were (0.88/0.96/0.94/0.83). When assessed on a per-vertex basis, the CoVs and ICCs for thickness/R1 had mean values of (2.9/1.9) and (0.82/0.68) across the regions of the DK Atlas. Retrospectively motion corrected MPnRAGE had significantly lower CoVs and higher ICCs for the morphological measures than PROMO MPRAGE. Motion correction effectively removed motion related biases in nearly all regions for R1 and morphometric measures. |
| first_indexed | 2024-12-16T12:55:42Z |
| format | Article |
| id | doaj.art-675996cdfa99470985873abd225a3a1a |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-16T12:55:42Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-675996cdfa99470985873abd225a3a1a2022-12-21T22:31:01ZengElsevierNeuroImage1095-95722021-11-01242118447FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correctionSteven Kecskemeti0Abigail Freeman1Brittany G Travers2Andrew L Alexander3Waisman Center, University of Wisconsin, Madison, United States; Radiology, University of Wisconsin, Madison, United States; Corresponding author at: T233 Waisman Center, 1500 Highland Avenue, Madison, WI 53705, United States.Waisman Center, University of Wisconsin, Madison, United States; Psychiatry, University of Wisconsin, Madison, United StatesKinesiology, University of Wisconsin, Madison, United StatesWaisman Center, University of Wisconsin, Madison, United States; Medical Physics, University of Wisconsin, Madison, United States; Psychiatry, University of Wisconsin, Madison, United StatesA test-retest study of FreeSurfer derived cortical thickness, cortical surface area, and cortical volume, as well as quantitative R1 relaxometry assessed on the midpoint of the cortex, was performed on a cohort of pediatric subjects (6-12 years old) scanned without sedation using SNARE-MPnRAGE (self navigated retrospective motion corrected magnetization prepared with n rapid gradient echoes) imaging. Reliability was assessed with coefficients of variation (CoVs) and intraclass correlation coefficients (ICCs) and statistical tests were used to determine differences with and without SNARE motion correction. Comparison of the test-retest measures of SNARE-MPnRAGE with prospectively motion corrected PROMO MPRAGE were also performed. When SNARE motion correction was used all parameters had statistically significant improvements and demonstrated high reliability. Reliability varied depending on parameter, region, and measurement type (vertex or region of interest). For mean thickness/surface area/volume/mean R1 across the regions of FreeSurfer's DK Atlas, the mean CoVs (% x100) were (1.2/1.6/1.9/0.9) and the mean ICCs were (0.88/0.96/0.94/0.83). When assessed on a per-vertex basis, the CoVs and ICCs for thickness/R1 had mean values of (2.9/1.9) and (0.82/0.68) across the regions of the DK Atlas. Retrospectively motion corrected MPnRAGE had significantly lower CoVs and higher ICCs for the morphological measures than PROMO MPRAGE. Motion correction effectively removed motion related biases in nearly all regions for R1 and morphometric measures.http://www.sciencedirect.com/science/article/pii/S1053811921007217CortexRelaxometryFreesurferMotionRetestReliability |
| spellingShingle | Steven Kecskemeti Abigail Freeman Brittany G Travers Andrew L Alexander FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction NeuroImage Cortex Relaxometry Freesurfer Motion Retest Reliability |
| title | FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction |
| title_full | FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction |
| title_fullStr | FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction |
| title_full_unstemmed | FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction |
| title_short | FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction |
| title_sort | freesurfer based cortical mapping and t1 relaxometry with mpnrage test retest reliability with and without retrospective motion correction |
| topic | Cortex Relaxometry Freesurfer Motion Retest Reliability |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921007217 |
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