PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS

PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS

Although it is well-recognized that inflammation enhances leukocyte bactericidal activity, the underlying mechanisms are not clear. Here we report that PRL2 is sensitive to oxidative stress at inflamed sites. Reduced PRL2 in phagocytes causes increased respiratory burst activity and enhances phagocy...

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Bibliographic Details
Main Authors: Cennan Yin, Chenyun Wu, Xinyue Du, Yan Fang, Juebiao Pu, Jianhua Wu, Lili Tang, Wei Zhao, Yongqiang Weng, Xiaokui Guo, Guangjie Chen, Zhaojun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
PRL2
oxidative burst
bactericidal activity
Rac GTPase
neutrophil
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02609/full

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