Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures
Based on van't Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution, mixing and solvation of acetaminophen in propylene glycol + water (PG + W) cosolvent mixtures, were evaluated from solubility data determined at several temperatures. The solubil...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2006-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000100018 |
| _version_ | 1818520217309937664 |
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| author | Jiménez Jackson A. Martínez Fleming |
| author_facet | Jiménez Jackson A. Martínez Fleming |
| author_sort | Jiménez Jackson A. |
| collection | DOAJ |
| description | Based on van't Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution, mixing and solvation of acetaminophen in propylene glycol + water (PG + W) cosolvent mixtures, were evaluated from solubility data determined at several temperatures. The solubility was greater at 100% of PG at all temperatures studied. The solvation of this drug in the mixtures increases as the PG proportion is also increased founding a maximum at 70% of PG. From 10% up to 20% of PG and from 70% up to 100% of PG, entropy driving was found, while from pure water up to 10% of PG and from 20% up to 70% of PG, enthalpy driving was found. These facts can be explained in terms of water-structure loss, and a diminishing in the energy required for cavity formation in the solvent, for mixtures from 30% up to 70% of PG. |
| first_indexed | 2024-12-11T01:34:22Z |
| format | Article |
| id | doaj.art-675b2b25ac7d4ee09e081c35f99ca529 |
| institution | Directory Open Access Journal |
| issn | 0103-5053 1678-4790 |
| language | English |
| last_indexed | 2024-12-11T01:34:22Z |
| publishDate | 2006-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-675b2b25ac7d4ee09e081c35f99ca5292022-12-22T01:25:16ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50531678-47902006-01-01171125134Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixturesJiménez Jackson A.Martínez FlemingBased on van't Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution, mixing and solvation of acetaminophen in propylene glycol + water (PG + W) cosolvent mixtures, were evaluated from solubility data determined at several temperatures. The solubility was greater at 100% of PG at all temperatures studied. The solvation of this drug in the mixtures increases as the PG proportion is also increased founding a maximum at 70% of PG. From 10% up to 20% of PG and from 70% up to 100% of PG, entropy driving was found, while from pure water up to 10% of PG and from 20% up to 70% of PG, enthalpy driving was found. These facts can be explained in terms of water-structure loss, and a diminishing in the energy required for cavity formation in the solvent, for mixtures from 30% up to 70% of PG.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000100018acetaminophensolubilitysolution thermodynamicsactivity coefficients |
| spellingShingle | Jiménez Jackson A. Martínez Fleming Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures Journal of the Brazilian Chemical Society acetaminophen solubility solution thermodynamics activity coefficients |
| title | Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures |
| title_full | Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures |
| title_fullStr | Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures |
| title_full_unstemmed | Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures |
| title_short | Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures |
| title_sort | thermodynamic study of the solubility of acetaminophen in propylene glycol water cosolvent mixtures |
| topic | acetaminophen solubility solution thermodynamics activity coefficients |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000100018 |
| work_keys_str_mv | AT jimenezjacksona thermodynamicstudyofthesolubilityofacetaminopheninpropyleneglycolwatercosolventmixtures AT martinezfleming thermodynamicstudyofthesolubilityofacetaminopheninpropyleneglycolwatercosolventmixtures |