| Summary: | Yan Wang,1 Shan Cong,1 Qinghua Zhang,1 Ranwei Li,2 Ke Wang1 1Department of Respiratory and Critical Care Medicine., The Second Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Urology, The Second Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Ke WangDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, 218 Ziqiang Street, Nanguan District, Changchun, Jilin Province 130041, People’s Republic of ChinaTel +86 18643111766Fax +86-431-81136820Email wke@jlu.edu.cnPurpose: Treatment of infections with Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases (ESBLs) is challenging due to the coexistence of multiple resistance mechanisms and the hypervirulent variant. Therefore, new targets or more effective treatment options aimed at ESBL-producing Klebsiella pneumoniae are urgently needed.Materials and Methods: Here, we collected ESBL-producing and non-ESBL Klebsiella pneumoniae isolates and studied their differences from a proteomic point of view.Results: We revealed treA, wza, gnd, rmlA, rmlC, rmlD, galE, aceE, and sucD as important virulence-related proteins in ESBL-producing Klebsiella pneumoniae, distinct from those in non-ESBL strains.Conclusion: Our findings provide plausible anti-virulence targets and suggest new therapeutic avenues against ESBL-producing Klebsiella pneumoniae.Keywords: Klebsiella pneumoniae, extended-spectrum beta-lactamases, proteomics, anti-virulence
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