Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case Study
Fahr’s disease is a rare idiopathic degenerative disease characterized by calcifications in the brain, and has also been associated with balance impairment. However, a detailed analysis of balance in these patients has not been performed. A 69-year-old woman with Fahr’s disease presented with a long...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.832170/full |
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| author | Stefano Scarano Stefano Scarano Viviana Rota Luigi Tesio Luigi Tesio Laura Perucca Laura Perucca Antonio Robecchi Majnardi Antonio Caronni |
| author_facet | Stefano Scarano Stefano Scarano Viviana Rota Luigi Tesio Luigi Tesio Laura Perucca Laura Perucca Antonio Robecchi Majnardi Antonio Caronni |
| author_sort | Stefano Scarano |
| collection | DOAJ |
| description | Fahr’s disease is a rare idiopathic degenerative disease characterized by calcifications in the brain, and has also been associated with balance impairment. However, a detailed analysis of balance in these patients has not been performed. A 69-year-old woman with Fahr’s disease presented with a long-lasting subjective imbalance. Balance was analyzed using both clinical (EquiScale, Timed Up and Go test, and Dizziness Handicap Inventory-short form) and instrumented tests (the sway of the body center of mass during quiet, perturbed, and self-perturbed stance, and the peak curvature of the center of mass during single stance while walking on a force-treadmill). The patient’s balance was normal during clinical tests and walking. However, during standing, a striking impairment in vestibular control of balance emerged. The balance behavior displayed mixed parkinsonian (e.g., slowness and reduced amplitude of movement) and cerebellar (e.g., increased sway during standing in all conditions and decomposition of movement) features, with a discrepancy between the high severity of the static and the low severity of the dynamic balance impairment. The balance impairment characteristics outlined in this study could help neurologists and physiatrists detect, stage, and treat this rare condition. |
| first_indexed | 2024-12-22T02:04:11Z |
| format | Article |
| id | doaj.art-6760d7a842824e92883e9733a3ced831 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T02:04:11Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-6760d7a842824e92883e9733a3ced8312022-12-21T18:42:33ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-03-011610.3389/fnhum.2022.832170832170Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case StudyStefano Scarano0Stefano Scarano1Viviana Rota2Luigi Tesio3Luigi Tesio4Laura Perucca5Laura Perucca6Antonio Robecchi Majnardi7Antonio Caronni8Department of Biomedical Sciences for Health, Università Degli Studi di Milano, Milan, ItalyDepartment of Neurorehabilitation Sciences, Ospedale San Luca, Istituto Auxologico Italiano IRCCS, Milan, ItalyDepartment of Neurorehabilitation Sciences, Ospedale San Luca, Istituto Auxologico Italiano IRCCS, Milan, ItalyDepartment of Biomedical Sciences for Health, Università Degli Studi di Milano, Milan, ItalyDepartment of Neurorehabilitation Sciences, Ospedale San Luca, Istituto Auxologico Italiano IRCCS, Milan, ItalyDepartment of Biomedical Sciences for Health, Università Degli Studi di Milano, Milan, ItalyDepartment of Neurorehabilitation Sciences, Ospedale San Luca, Istituto Auxologico Italiano IRCCS, Milan, ItalyDepartment of Neurorehabilitation Sciences, Ospedale San Luca, Istituto Auxologico Italiano IRCCS, Milan, ItalyDepartment of Neurorehabilitation Sciences, Ospedale San Luca, Istituto Auxologico Italiano IRCCS, Milan, ItalyFahr’s disease is a rare idiopathic degenerative disease characterized by calcifications in the brain, and has also been associated with balance impairment. However, a detailed analysis of balance in these patients has not been performed. A 69-year-old woman with Fahr’s disease presented with a long-lasting subjective imbalance. Balance was analyzed using both clinical (EquiScale, Timed Up and Go test, and Dizziness Handicap Inventory-short form) and instrumented tests (the sway of the body center of mass during quiet, perturbed, and self-perturbed stance, and the peak curvature of the center of mass during single stance while walking on a force-treadmill). The patient’s balance was normal during clinical tests and walking. However, during standing, a striking impairment in vestibular control of balance emerged. The balance behavior displayed mixed parkinsonian (e.g., slowness and reduced amplitude of movement) and cerebellar (e.g., increased sway during standing in all conditions and decomposition of movement) features, with a discrepancy between the high severity of the static and the low severity of the dynamic balance impairment. The balance impairment characteristics outlined in this study could help neurologists and physiatrists detect, stage, and treat this rare condition.https://www.frontiersin.org/articles/10.3389/fnhum.2022.832170/fullFahr’s diseasebilateral striopallidodentate calcinosisbalancecenter of massposturographygait analysis |
| spellingShingle | Stefano Scarano Stefano Scarano Viviana Rota Luigi Tesio Luigi Tesio Laura Perucca Laura Perucca Antonio Robecchi Majnardi Antonio Caronni Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case Study Frontiers in Human Neuroscience Fahr’s disease bilateral striopallidodentate calcinosis balance center of mass posturography gait analysis |
| title | Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case Study |
| title_full | Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case Study |
| title_fullStr | Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case Study |
| title_full_unstemmed | Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case Study |
| title_short | Balance Impairment in Fahr’s Disease: Mixed Signs of Parkinsonism and Cerebellar Disorder. A Case Study |
| title_sort | balance impairment in fahr s disease mixed signs of parkinsonism and cerebellar disorder a case study |
| topic | Fahr’s disease bilateral striopallidodentate calcinosis balance center of mass posturography gait analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.832170/full |
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