The Alternative Complement System Mediates Cell Death in Retinal Ischemia Reperfusion Injury

The Alternative Complement System Mediates Cell Death in Retinal Ischemia Reperfusion Injury

Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Previous studies suggest that the complement cascade plays a key role in IR injury in several systemic diseases. However, the role of the complement pathway in the ischemic retina has not been investiga...

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Bibliographic Details
Main Authors: Saori Inafuku, Garrett Klokman, Kip M. Connor
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
retina
complement system
ischemia reperfusion
endothelial cell
shear stress
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00278/full

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