Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development
Liver cancer is a malignancy developed from underlying liver disease that encompasses liver injury and metabolic disorders. The progression from these underlying liver disease to cancer is accompanied by chronic inflammatory conditions in which liver macrophages play important roles in orchestrating...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1098467/full |
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| author | Mario M. Alba Brandon Ebright Brittney Hua Ielyzaveta Slarve Yiren Zhou Yunyi Jia Stan G. Louie Bangyan L. Stiles Bangyan L. Stiles |
| author_facet | Mario M. Alba Brandon Ebright Brittney Hua Ielyzaveta Slarve Yiren Zhou Yunyi Jia Stan G. Louie Bangyan L. Stiles Bangyan L. Stiles |
| author_sort | Mario M. Alba |
| collection | DOAJ |
| description | Liver cancer is a malignancy developed from underlying liver disease that encompasses liver injury and metabolic disorders. The progression from these underlying liver disease to cancer is accompanied by chronic inflammatory conditions in which liver macrophages play important roles in orchestrating the inflammatory response. During this process, bioactive lipids produced by hepatocytes and macrophages mediate the inflammatory responses by acting as pro-inflammatory factors, as well as, playing roles in the resolution of inflammation conditions. Here, we review the literature discussing the roles of bioactive lipids in acute and chronic hepatic inflammation and progression to cancer. |
| first_indexed | 2024-04-10T18:16:55Z |
| format | Article |
| id | doaj.art-6763cc456c964e20abb8e8bec18630f7 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T18:16:55Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-6763cc456c964e20abb8e8bec18630f72023-02-02T08:19:39ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-02-011410.3389/fphys.2023.10984671098467Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer developmentMario M. Alba0Brandon Ebright1Brittney Hua2Ielyzaveta Slarve3Yiren Zhou4Yunyi Jia5Stan G. Louie6Bangyan L. Stiles7Bangyan L. Stiles8Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesClinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesClinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, Unites StatesPathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, Unites StatesLiver cancer is a malignancy developed from underlying liver disease that encompasses liver injury and metabolic disorders. The progression from these underlying liver disease to cancer is accompanied by chronic inflammatory conditions in which liver macrophages play important roles in orchestrating the inflammatory response. During this process, bioactive lipids produced by hepatocytes and macrophages mediate the inflammatory responses by acting as pro-inflammatory factors, as well as, playing roles in the resolution of inflammation conditions. Here, we review the literature discussing the roles of bioactive lipids in acute and chronic hepatic inflammation and progression to cancer.https://www.frontiersin.org/articles/10.3389/fphys.2023.1098467/fullHCCliver steatosisPUFAeicosanoidsoxylipin |
| spellingShingle | Mario M. Alba Brandon Ebright Brittney Hua Ielyzaveta Slarve Yiren Zhou Yunyi Jia Stan G. Louie Bangyan L. Stiles Bangyan L. Stiles Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development Frontiers in Physiology HCC liver steatosis PUFA eicosanoids oxylipin |
| title | Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development |
| title_full | Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development |
| title_fullStr | Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development |
| title_full_unstemmed | Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development |
| title_short | Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development |
| title_sort | eicosanoids and other oxylipins in liver injury inflammation and liver cancer development |
| topic | HCC liver steatosis PUFA eicosanoids oxylipin |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1098467/full |
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