Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS
Background The role of adipokine dysregulation in determining the metabolic fate of obesity is not well studied. We aimed to examine whether the matricellular protein osteonectin and the profiles of certain adipokines could differentiate metabolically healthy obese (MHO) versus metabolically unhealt...
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| Format: | Article |
| Language: | English |
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Wiley
2018-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.009169 |
| _version_ | 1819205502406492160 |
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| author | Junling Fu Yu Li Issy C. Esangbedo Ge Li Dan Feng Lujiao Li Lu Xu Lanwen Han Mingyao Li Changhong Li Shan Gao Ming Li Steven. M. Willi |
| author_facet | Junling Fu Yu Li Issy C. Esangbedo Ge Li Dan Feng Lujiao Li Lu Xu Lanwen Han Mingyao Li Changhong Li Shan Gao Ming Li Steven. M. Willi |
| author_sort | Junling Fu |
| collection | DOAJ |
| description | Background The role of adipokine dysregulation in determining the metabolic fate of obesity is not well studied. We aimed to examine whether the matricellular protein osteonectin and the profiles of certain adipokines could differentiate metabolically healthy obese (MHO) versus metabolically unhealthy obese phenotypes in childhood. Methods and Results This study included 1137 obese children and 982 normal‐weight healthy (NWH) controls recruited from the BCAMS (Beijing Child and Adolescent Metabolic Syndrome) study. MHO was defined by the absence of insulin resistance and/or any metabolic syndrome components. Six adipokines—osteonectin, leptin, adiponectin, resistin, FGF21 (fibroblast growth factor 21), and RBP‐4 (retinol binding protein 4)—were assessed. Approximately 20% of obese children displayed the MHO phenotype. MHO children had a more favorable adipokine profile than metabolically unhealthy obese children, with lower osteonectin, leptin, and RBP‐4 and higher adiponectin (all P<0.05). Compared with normal‐weight healthy controls, MHO children displayed increased leptin, resistin, and RBP‐4 levels and reduced adiponectin concentrations (all P<0.05) but similar osteonectin and FGF21 levels. Among obese subjects, decreased osteonectin (odds ratio [OR]: 0.82; 95% confidence interval [CI] per standard deviation, 0.70–0.97), RBP‐4 (OR: 0.77; 95% CI per standard deviation, 0.64–0.93), and leptin/adiponectin ratio (OR: 0.58; 95% CI per standard deviation, 0.43–0.77) were independent predictors of MHO. In addition, compared with children without abnormalities, those with any 3 adipokine abnormalities were 80% less likely to exhibit the MHO phenotype (OR: 0.20; 95% CI, 0.10–0.43) and 3 times more likely to have metabolic syndrome (OR: 2.77; 95% CI, 1.52–5.03). Conclusions These findings suggest that dysregulation of adipokines might govern the metabolic consequences of obesity in children. Low osteonectin levels, along with a healthy adipokine profile, might be used as an early marker of the MHO phenotype. |
| first_indexed | 2024-12-23T04:52:43Z |
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| id | doaj.art-6763d5265114422f808e80d5f3268462 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-23T04:52:43Z |
| publishDate | 2018-12-01 |
| publisher | Wiley |
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| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-6763d5265114422f808e80d5f32684622022-12-21T17:59:24ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802018-12-0172310.1161/JAHA.118.009169Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMSJunling Fu0Yu Li1Issy C. Esangbedo2Ge Li3Dan Feng4Lujiao Li5Lu Xu6Lanwen Han7Mingyao Li8Changhong Li9Shan Gao10Ming Li11Steven. M. Willi12Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing ChinaDepartment of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing ChinaHealth Weight Program The Children's Hospital of Philadelphia Perelman School of Medicine at University of Pennsylvania Philadelphia PADepartment of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing ChinaDepartment of Endocrinology Beijing Chaoyang Hospital Capital Medical University Beijing ChinaDepartment of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing ChinaDepartment of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing ChinaDepartment of Endocrinology Beijing Chaoyang Hospital Capital Medical University Beijing ChinaDepartments of Biostatistics and Epidemiology University of Pennsylvania Philadelphia PADepartments of Endocrinology/Diabetes The Children's Hospital of Philadelphia Perelman School of Medicine University of Pennsylvania Philadelphia PADepartment of Endocrinology Beijing Chaoyang Hospital Capital Medical University Beijing ChinaDepartment of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing ChinaDepartment of Endocrinology/Diabetes Children's Hospital of Philadelphia PABackground The role of adipokine dysregulation in determining the metabolic fate of obesity is not well studied. We aimed to examine whether the matricellular protein osteonectin and the profiles of certain adipokines could differentiate metabolically healthy obese (MHO) versus metabolically unhealthy obese phenotypes in childhood. Methods and Results This study included 1137 obese children and 982 normal‐weight healthy (NWH) controls recruited from the BCAMS (Beijing Child and Adolescent Metabolic Syndrome) study. MHO was defined by the absence of insulin resistance and/or any metabolic syndrome components. Six adipokines—osteonectin, leptin, adiponectin, resistin, FGF21 (fibroblast growth factor 21), and RBP‐4 (retinol binding protein 4)—were assessed. Approximately 20% of obese children displayed the MHO phenotype. MHO children had a more favorable adipokine profile than metabolically unhealthy obese children, with lower osteonectin, leptin, and RBP‐4 and higher adiponectin (all P<0.05). Compared with normal‐weight healthy controls, MHO children displayed increased leptin, resistin, and RBP‐4 levels and reduced adiponectin concentrations (all P<0.05) but similar osteonectin and FGF21 levels. Among obese subjects, decreased osteonectin (odds ratio [OR]: 0.82; 95% confidence interval [CI] per standard deviation, 0.70–0.97), RBP‐4 (OR: 0.77; 95% CI per standard deviation, 0.64–0.93), and leptin/adiponectin ratio (OR: 0.58; 95% CI per standard deviation, 0.43–0.77) were independent predictors of MHO. In addition, compared with children without abnormalities, those with any 3 adipokine abnormalities were 80% less likely to exhibit the MHO phenotype (OR: 0.20; 95% CI, 0.10–0.43) and 3 times more likely to have metabolic syndrome (OR: 2.77; 95% CI, 1.52–5.03). Conclusions These findings suggest that dysregulation of adipokines might govern the metabolic consequences of obesity in children. Low osteonectin levels, along with a healthy adipokine profile, might be used as an early marker of the MHO phenotype.https://www.ahajournals.org/doi/10.1161/JAHA.118.009169adipokinechildrenmetabolic syndromemetabolismobesityosteonectin |
| spellingShingle | Junling Fu Yu Li Issy C. Esangbedo Ge Li Dan Feng Lujiao Li Lu Xu Lanwen Han Mingyao Li Changhong Li Shan Gao Ming Li Steven. M. Willi Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease adipokine children metabolic syndrome metabolism obesity osteonectin |
| title | Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS |
| title_full | Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS |
| title_fullStr | Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS |
| title_full_unstemmed | Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS |
| title_short | Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS |
| title_sort | circulating osteonectin and adipokine profiles in relation to metabolically healthy obesity in chinese children findings from bcams |
| topic | adipokine children metabolic syndrome metabolism obesity osteonectin |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.009169 |
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