Renal Side Effects of COVID-19 Vaccination
<b>Background</b>: The COVID-19 pandemic has imposed a challenge on global healthcare and has tremendously impacted everyone’s lives. Vaccination is one of the most effective and vital strategies to halt the pandemic. However, new-onset and relapsed kidney diseases have been reported aft...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/11/1783 |
| _version_ | 1797466320972808192 |
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| author | Junfeng Zhang Jiajia Cao Qing Ye |
| author_facet | Junfeng Zhang Jiajia Cao Qing Ye |
| author_sort | Junfeng Zhang |
| collection | DOAJ |
| description | <b>Background</b>: The COVID-19 pandemic has imposed a challenge on global healthcare and has tremendously impacted everyone’s lives. Vaccination is one of the most effective and vital strategies to halt the pandemic. However, new-onset and relapsed kidney diseases have been reported after COVID-19 vaccination. This narrative review was conducted to collect published data and generalize some hypotheses for the pathogenesis of renal side effects of COVID-19 vaccines. <b>Methods</b>: A systematic literature search of articles reporting renal adverse reactions, including in adults and children, in the PubMed and Web of Science databases until August 2022 was performed. <b>Results</b>: A total of 130 cases reporting a renal adverse reaction following COVID-19 vaccination from 90 articles were included in this review, of which 90 (69%) were new-onset kidney diseases, while 40 (31%) were relapsed kidney diseases. The most frequent renal side effects of COVID-19 vaccination were minimal change disease (52 cases), IgA nephropathy (48 cases), antineutrophil cytoplasmic autoantibody vasculitis (16 cases), and acute interstitial nephritis (12 cases). Other renal side effects occurred at a much lower frequency. Follow-up data were available for 105 patients, and 100 patients (95%) responded to the treatments. <b>Conclusions</b>: The number of reported cases is far less than the hundreds of millions of vaccinations, and the benefit of COVID-19 vaccination far outweighs its risks. This review will assist healthcare professionals, particularly nephrologists, who should be aware of these side effects and recognize them early and treat them efficiently. |
| first_indexed | 2024-03-09T18:35:14Z |
| format | Article |
| id | doaj.art-676469554cd34bef82b9141d1fe60abf |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T18:35:14Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-676469554cd34bef82b9141d1fe60abf2023-11-24T07:12:38ZengMDPI AGVaccines2076-393X2022-10-011011178310.3390/vaccines10111783Renal Side Effects of COVID-19 VaccinationJunfeng Zhang0Jiajia Cao1Qing Ye2Department of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou 310052, ChinaDepartment of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou 310052, ChinaDepartment of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou 310052, China<b>Background</b>: The COVID-19 pandemic has imposed a challenge on global healthcare and has tremendously impacted everyone’s lives. Vaccination is one of the most effective and vital strategies to halt the pandemic. However, new-onset and relapsed kidney diseases have been reported after COVID-19 vaccination. This narrative review was conducted to collect published data and generalize some hypotheses for the pathogenesis of renal side effects of COVID-19 vaccines. <b>Methods</b>: A systematic literature search of articles reporting renal adverse reactions, including in adults and children, in the PubMed and Web of Science databases until August 2022 was performed. <b>Results</b>: A total of 130 cases reporting a renal adverse reaction following COVID-19 vaccination from 90 articles were included in this review, of which 90 (69%) were new-onset kidney diseases, while 40 (31%) were relapsed kidney diseases. The most frequent renal side effects of COVID-19 vaccination were minimal change disease (52 cases), IgA nephropathy (48 cases), antineutrophil cytoplasmic autoantibody vasculitis (16 cases), and acute interstitial nephritis (12 cases). Other renal side effects occurred at a much lower frequency. Follow-up data were available for 105 patients, and 100 patients (95%) responded to the treatments. <b>Conclusions</b>: The number of reported cases is far less than the hundreds of millions of vaccinations, and the benefit of COVID-19 vaccination far outweighs its risks. This review will assist healthcare professionals, particularly nephrologists, who should be aware of these side effects and recognize them early and treat them efficiently.https://www.mdpi.com/2076-393X/10/11/1783COVID-19 vaccinationside effectadverse reactionkidney diseaserenalSARS-CoV-2 |
| spellingShingle | Junfeng Zhang Jiajia Cao Qing Ye Renal Side Effects of COVID-19 Vaccination Vaccines COVID-19 vaccination side effect adverse reaction kidney disease renal SARS-CoV-2 |
| title | Renal Side Effects of COVID-19 Vaccination |
| title_full | Renal Side Effects of COVID-19 Vaccination |
| title_fullStr | Renal Side Effects of COVID-19 Vaccination |
| title_full_unstemmed | Renal Side Effects of COVID-19 Vaccination |
| title_short | Renal Side Effects of COVID-19 Vaccination |
| title_sort | renal side effects of covid 19 vaccination |
| topic | COVID-19 vaccination side effect adverse reaction kidney disease renal SARS-CoV-2 |
| url | https://www.mdpi.com/2076-393X/10/11/1783 |
| work_keys_str_mv | AT junfengzhang renalsideeffectsofcovid19vaccination AT jiajiacao renalsideeffectsofcovid19vaccination AT qingye renalsideeffectsofcovid19vaccination |