The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
Currently, there is an increasing number of people with mild cognitive (MCI) impairment and dementia (D). In the present work we studied the role of tau protein, β-amyloid, LPS (lipopolysaccharide), and curli protein of elderly adults with MCI or D and the contribution of gut microbiota. Four groups...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/4/932 |
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| author | Mónica Sánchez-Tapia Alberto Mimenza-Alvarado Lizbeth Granados-Domínguez Adriana Flores-López Adriana López-Barradas Victor Ortiz Claudia Pérez-Cruz Hilda Sánchez-Vidal Julieta Hernández-Acosta José Alberto Ávila-Funes Martha Guevara-Cruz Armando R. Tovar Nimbe Torres |
| author_facet | Mónica Sánchez-Tapia Alberto Mimenza-Alvarado Lizbeth Granados-Domínguez Adriana Flores-López Adriana López-Barradas Victor Ortiz Claudia Pérez-Cruz Hilda Sánchez-Vidal Julieta Hernández-Acosta José Alberto Ávila-Funes Martha Guevara-Cruz Armando R. Tovar Nimbe Torres |
| author_sort | Mónica Sánchez-Tapia |
| collection | DOAJ |
| description | Currently, there is an increasing number of people with mild cognitive (MCI) impairment and dementia (D). In the present work we studied the role of tau protein, β-amyloid, LPS (lipopolysaccharide), and curli protein of elderly adults with MCI or D and the contribution of gut microbiota. Four groups were studied: young subjects, healthy adults older than 60 years (A), elderly adults with MCI (MCI), and elderly adults with dementia (D). A preclinical study was conducted in old male Wistar rats to evaluate the impact of gut microbiota on curli protein abundance in feces and brain. The results showed that with increasing age, tau protein, β-amyloid, and LPS significantly increased in serum during MCI and D, and this was associated with an increase in the abundance of <i>E. coli</i> that synthesize the amyloid protein curli, that may promote the aggregation of amyloid proteins. Rats showed a clear increase in the abundance of curli protein in the brain during aging. Thus, cognitive impairment and dementia are in part due to an alteration in the gut microbiota–brain axis via increase in curli protein and LPS leading to an increase in tau and β-amyloid protein. |
| first_indexed | 2024-03-11T08:18:56Z |
| format | Article |
| id | doaj.art-6768c081913e4e368cb450510ec2dc3c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T08:18:56Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6768c081913e4e368cb450510ec2dc3c2023-11-16T22:30:57ZengMDPI AGNutrients2072-66432023-02-0115493210.3390/nu15040932The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in StoolMónica Sánchez-Tapia0Alberto Mimenza-Alvarado1Lizbeth Granados-Domínguez2Adriana Flores-López3Adriana López-Barradas4Victor Ortiz5Claudia Pérez-Cruz6Hilda Sánchez-Vidal7Julieta Hernández-Acosta8José Alberto Ávila-Funes9Martha Guevara-Cruz10Armando R. Tovar11Nimbe Torres12Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Geriatria, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoLaboratorio de Neuroplasticidad y Neurodegeneración, Departamento de Farmacología, CINVESTAV, Mexico City 07360, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Geriatria, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, MexicoCurrently, there is an increasing number of people with mild cognitive (MCI) impairment and dementia (D). In the present work we studied the role of tau protein, β-amyloid, LPS (lipopolysaccharide), and curli protein of elderly adults with MCI or D and the contribution of gut microbiota. Four groups were studied: young subjects, healthy adults older than 60 years (A), elderly adults with MCI (MCI), and elderly adults with dementia (D). A preclinical study was conducted in old male Wistar rats to evaluate the impact of gut microbiota on curli protein abundance in feces and brain. The results showed that with increasing age, tau protein, β-amyloid, and LPS significantly increased in serum during MCI and D, and this was associated with an increase in the abundance of <i>E. coli</i> that synthesize the amyloid protein curli, that may promote the aggregation of amyloid proteins. Rats showed a clear increase in the abundance of curli protein in the brain during aging. Thus, cognitive impairment and dementia are in part due to an alteration in the gut microbiota–brain axis via increase in curli protein and LPS leading to an increase in tau and β-amyloid protein.https://www.mdpi.com/2072-6643/15/4/932dementiaintestinal microbiotaβ-amyloidtau proteincurli proteinLPS |
| spellingShingle | Mónica Sánchez-Tapia Alberto Mimenza-Alvarado Lizbeth Granados-Domínguez Adriana Flores-López Adriana López-Barradas Victor Ortiz Claudia Pérez-Cruz Hilda Sánchez-Vidal Julieta Hernández-Acosta José Alberto Ávila-Funes Martha Guevara-Cruz Armando R. Tovar Nimbe Torres The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool Nutrients dementia intestinal microbiota β-amyloid tau protein curli protein LPS |
| title | The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool |
| title_full | The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool |
| title_fullStr | The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool |
| title_full_unstemmed | The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool |
| title_short | The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool |
| title_sort | gut microbiota brain axis during aging mild cognitive impairment and dementia role of tau protein β amyloid and lps in serum and curli protein in stool |
| topic | dementia intestinal microbiota β-amyloid tau protein curli protein LPS |
| url | https://www.mdpi.com/2072-6643/15/4/932 |
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