Nuclear receptors and skeletal muscle fiber type
The contractile and metabolic properties of skeletal muscle depend on muscle fiber type composition. There are two major fiber types: type 1 fibers (slow-twitch oxidative) and type 2 fibers (fast-twitch glycolytic). Muscle fiber type is a critical physiological property that affects sports performan...
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| Format: | Article |
| Language: | English |
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Japanese Society of Physical Fitness and Sports Medicine
2015-07-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
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| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/4/3/4_259/_pdf/-char/en |
| _version_ | 1824020070957842432 |
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| author | Wataru Mizunoya |
| author_facet | Wataru Mizunoya |
| author_sort | Wataru Mizunoya |
| collection | DOAJ |
| description | The contractile and metabolic properties of skeletal muscle depend on muscle fiber type composition. There are two major fiber types: type 1 fibers (slow-twitch oxidative) and type 2 fibers (fast-twitch glycolytic). Muscle fiber type is a critical physiological property that affects sports performance and metabolic ability. To date, natural food components have not been regarded as regulators of skeletal muscle fiber type. Meanwhile, in the present century, it has been revealed that several nuclear receptors (NRs) and their cofactors affect skeletal muscle fiber type independently from muscular contraction. Interestingly, many compounds from natural food sources have been identified as NR ligands. These facts indicate the possibility of the regulation of muscle fiber type by food components. In this review, we present an overview of the current knowledge of the role of NRs and their cofactors in skeletal muscle fiber type and discuss the perspective of muscle fiber type regulation by food components via NR. |
| first_indexed | 2024-12-19T01:27:27Z |
| format | Article |
| id | doaj.art-6768d76292d945d2a0618b0e46ca5c39 |
| institution | Directory Open Access Journal |
| issn | 2186-8131 2186-8123 |
| language | English |
| last_indexed | 2024-12-19T01:27:27Z |
| publishDate | 2015-07-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj.art-6768d76292d945d2a0618b0e46ca5c392022-12-21T20:42:12ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232015-07-014325927010.7600/jpfsm.4.259jpfsmNuclear receptors and skeletal muscle fiber typeWataru Mizunoya0Department of Bioresource Sciences, Faculty of Agriculture, Kyushu UniversityThe contractile and metabolic properties of skeletal muscle depend on muscle fiber type composition. There are two major fiber types: type 1 fibers (slow-twitch oxidative) and type 2 fibers (fast-twitch glycolytic). Muscle fiber type is a critical physiological property that affects sports performance and metabolic ability. To date, natural food components have not been regarded as regulators of skeletal muscle fiber type. Meanwhile, in the present century, it has been revealed that several nuclear receptors (NRs) and their cofactors affect skeletal muscle fiber type independently from muscular contraction. Interestingly, many compounds from natural food sources have been identified as NR ligands. These facts indicate the possibility of the regulation of muscle fiber type by food components. In this review, we present an overview of the current knowledge of the role of NRs and their cofactors in skeletal muscle fiber type and discuss the perspective of muscle fiber type regulation by food components via NR.https://www.jstage.jst.go.jp/article/jpfsm/4/3/4_259/_pdf/-char/enskeletal musclefiber typenuclear receptorsnuclear receptor cofactorsfood componentsmyosin heavy chain |
| spellingShingle | Wataru Mizunoya Nuclear receptors and skeletal muscle fiber type Journal of Physical Fitness and Sports Medicine skeletal muscle fiber type nuclear receptors nuclear receptor cofactors food components myosin heavy chain |
| title | Nuclear receptors and skeletal muscle fiber type |
| title_full | Nuclear receptors and skeletal muscle fiber type |
| title_fullStr | Nuclear receptors and skeletal muscle fiber type |
| title_full_unstemmed | Nuclear receptors and skeletal muscle fiber type |
| title_short | Nuclear receptors and skeletal muscle fiber type |
| title_sort | nuclear receptors and skeletal muscle fiber type |
| topic | skeletal muscle fiber type nuclear receptors nuclear receptor cofactors food components myosin heavy chain |
| url | https://www.jstage.jst.go.jp/article/jpfsm/4/3/4_259/_pdf/-char/en |
| work_keys_str_mv | AT watarumizunoya nuclearreceptorsandskeletalmusclefibertype |