Late-stage MC38 tumours recapitulate features of human colorectal cancer – implications for appropriate timepoint selection in preclinical studies

Late-stage MC38 tumours recapitulate features of human colorectal cancer – implications for appropriate timepoint selection in preclinical studies

Anti-tumour T cell responses play a crucial role in controlling the progression of colorectal cancer (CRC), making this disease a promising candidate for immunotherapy. However, responses to immune-targeted therapies are currently limited to subpopulations of patients and specific types of cancer. C...

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Bibliographic Details
Main Authors: Nicholas J. Shields, Estelle M. Peyroux, Angela L. Ferguson, Megan Steain, Silke Neumann, Sarah L. Young
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
immunotherapy
syngeneic preclinical models
MC38
immune exclusion
t cell exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152035/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152035/full

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