Targeting CLL-1 for acute myeloid leukemia therapy
Abstract Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing number of targets such as CD33, CD123, CLL-1, CD47, CD7...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-019-0726-5 |
| _version_ | 1818539297098170368 |
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| author | Hongbing Ma Iyer Swaminathan Padmanabhan Simrit Parmar Yuping Gong |
| author_facet | Hongbing Ma Iyer Swaminathan Padmanabhan Simrit Parmar Yuping Gong |
| author_sort | Hongbing Ma |
| collection | DOAJ |
| description | Abstract Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing number of targets such as CD33, CD123, CLL-1, CD47, CD70, and TIM3, have been developed for immunotherapy of AML. Among them, CLL-1 has attracted the researchers’ attention due to its high expression in AML while being absent in normal hematopoietic stem cell. Accumulating evidence have demonstrated CLL-1 is an ideal target for AML. In this paper, we will review the expression of CLL-1 on normal cells and AML, the value of CLL-1 in diagnosis and follow-up, and targeting CLL-1 therapy-based antibody and chimeric antigen receptor T cell therapy as well as providing an overview of CLL-1 as a target for AML. |
| first_indexed | 2024-12-11T21:40:11Z |
| format | Article |
| id | doaj.art-676c89746d2741368482135227ee051c |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-11T21:40:11Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-676c89746d2741368482135227ee051c2022-12-22T00:49:51ZengBMCJournal of Hematology & Oncology1756-87222019-04-0112111110.1186/s13045-019-0726-5Targeting CLL-1 for acute myeloid leukemia therapyHongbing Ma0Iyer Swaminathan Padmanabhan1Simrit Parmar2Yuping Gong3Hematology Department, West China Hospital, Sichuan UniversityDepartment of Lymphoma and Myeloma, MD Anderson Cancer Center, Texas UniversityDepartment of Lymphoma and Myeloma, MD Anderson Cancer Center, Texas UniversityHematology Department, West China Hospital, Sichuan UniversityAbstract Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing number of targets such as CD33, CD123, CLL-1, CD47, CD70, and TIM3, have been developed for immunotherapy of AML. Among them, CLL-1 has attracted the researchers’ attention due to its high expression in AML while being absent in normal hematopoietic stem cell. Accumulating evidence have demonstrated CLL-1 is an ideal target for AML. In this paper, we will review the expression of CLL-1 on normal cells and AML, the value of CLL-1 in diagnosis and follow-up, and targeting CLL-1 therapy-based antibody and chimeric antigen receptor T cell therapy as well as providing an overview of CLL-1 as a target for AML.http://link.springer.com/article/10.1186/s13045-019-0726-5Acute myeloid leukemiaCLL-1CLEC12ADCAL-2hMICLCD371 |
| spellingShingle | Hongbing Ma Iyer Swaminathan Padmanabhan Simrit Parmar Yuping Gong Targeting CLL-1 for acute myeloid leukemia therapy Journal of Hematology & Oncology Acute myeloid leukemia CLL-1 CLEC12A DCAL-2 hMICL CD371 |
| title | Targeting CLL-1 for acute myeloid leukemia therapy |
| title_full | Targeting CLL-1 for acute myeloid leukemia therapy |
| title_fullStr | Targeting CLL-1 for acute myeloid leukemia therapy |
| title_full_unstemmed | Targeting CLL-1 for acute myeloid leukemia therapy |
| title_short | Targeting CLL-1 for acute myeloid leukemia therapy |
| title_sort | targeting cll 1 for acute myeloid leukemia therapy |
| topic | Acute myeloid leukemia CLL-1 CLEC12A DCAL-2 hMICL CD371 |
| url | http://link.springer.com/article/10.1186/s13045-019-0726-5 |
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