Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments
Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/12/21127 |
| _version_ | 1819037364523106304 |
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| author | Liza Vecchi Brumatti Annalisa Marcuzzi Paola Maura Tricarico Valentina Zanin Martina Girardelli Anna Monica Bianco |
| author_facet | Liza Vecchi Brumatti Annalisa Marcuzzi Paola Maura Tricarico Valentina Zanin Martina Girardelli Anna Monica Bianco |
| author_sort | Liza Vecchi Brumatti |
| collection | DOAJ |
| description | Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn’s disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-κB) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC. |
| first_indexed | 2024-12-21T08:20:15Z |
| format | Article |
| id | doaj.art-676c8b8c3b114ce39724c84de7180e82 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T08:20:15Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-676c8b8c3b114ce39724c84de7180e822022-12-21T19:10:27ZengMDPI AGMolecules1420-30492014-12-011912211272115310.3390/molecules191221127molecules191221127Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative TreatmentsLiza Vecchi Brumatti0Annalisa Marcuzzi1Paola Maura Tricarico2Valentina Zanin3Martina Girardelli4Anna Monica Bianco5Institute for Maternal and Child Health—IRCCS "Burlo Garofolo"—via dell'Istria, 65/1, Trieste 34137, ItalyInstitute for Maternal and Child Health—IRCCS "Burlo Garofolo"—via dell'Istria, 65/1, Trieste 34137, ItalyDepartment of Medicine and Surgery and Health Sciences, University of Trieste, Piazzale Europa, 1, Trieste 34137, ItalyInstitute for Maternal and Child Health—IRCCS "Burlo Garofolo"—via dell'Istria, 65/1, Trieste 34137, ItalyInstitute for Maternal and Child Health—IRCCS "Burlo Garofolo"—via dell'Istria, 65/1, Trieste 34137, ItalyInstitute for Maternal and Child Health—IRCCS "Burlo Garofolo"—via dell'Istria, 65/1, Trieste 34137, ItalyCurcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn’s disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-κB) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC.http://www.mdpi.com/1420-3049/19/12/21127curcumininflammatory bowel disease (IBD)inflammationinnovative treatments |
| spellingShingle | Liza Vecchi Brumatti Annalisa Marcuzzi Paola Maura Tricarico Valentina Zanin Martina Girardelli Anna Monica Bianco Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments Molecules curcumin inflammatory bowel disease (IBD) inflammation innovative treatments |
| title | Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments |
| title_full | Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments |
| title_fullStr | Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments |
| title_full_unstemmed | Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments |
| title_short | Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments |
| title_sort | curcumin and inflammatory bowel disease potential and limits of innovative treatments |
| topic | curcumin inflammatory bowel disease (IBD) inflammation innovative treatments |
| url | http://www.mdpi.com/1420-3049/19/12/21127 |
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