Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, and several studies have suggested possible early RV involvement. Aim of the study was to evaluate the 3D echo parameters of the right ventricle (RV) and the metabolomic profile to correlate both with SLE severity. Forty SLE patie...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/7/781 |
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| author | Martino Deidda Antonio Noto Davide Firinu Cristina Piras William Cordeddu Claudia Depau Giulia Costanzo Stefano Del Giacco Luigi Atzori Giuseppe Mercuro Christian Cadeddu Dessalvi |
| author_facet | Martino Deidda Antonio Noto Davide Firinu Cristina Piras William Cordeddu Claudia Depau Giulia Costanzo Stefano Del Giacco Luigi Atzori Giuseppe Mercuro Christian Cadeddu Dessalvi |
| author_sort | Martino Deidda |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, and several studies have suggested possible early RV involvement. Aim of the study was to evaluate the 3D echo parameters of the right ventricle (RV) and the metabolomic profile to correlate both with SLE severity. Forty SLE patients, free of cardiovascular disease, were enrolled and the following 3D parameters were evaluated: the RV ejection fraction (RV-EF), longitudinal strain of the interventricular septum (Septal LS), longitudinal strain of the free wall (Free-LS) and the fractional area change (FAC). In addition, a metabolomic analysis was performed. Direct correlations were observed between TAPSE values and the RV 3D parameters. Then, when splitting the population according to the SDI value, it was found that patients with higher cumulative damage (≥3) had significantly lower FAC, RV-EF, Septal LS, and Free-LS values; the latter three parameters showed a significant correlation with the metabolic profile of the patients. Furthermore, the division based on SDI values identified different metabolic profiles related to the degree of RV dysfunction. The RV dysfunction induced by the chronic inflammatory state present in SLE can be identified early by 3D echocardiography. Its severity seems to be related to systemic organ damage and the results associated with a specific metabolic fingerprint constituted by 2,4-dihydroxybutyric acid, 3,4-dihydroxybutyric acid, citric acid, glucose, glutamine, glycine, linoleic acid, oleic acid, phosphate, urea, and valine. |
| first_indexed | 2024-03-11T00:50:51Z |
| format | Article |
| id | doaj.art-676d8bcb6e214a1f84ceb924dec8a15b |
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| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T00:50:51Z |
| publishDate | 2023-06-01 |
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| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-676d8bcb6e214a1f84ceb924dec8a15b2023-11-18T20:27:06ZengMDPI AGMetabolites2218-19892023-06-0113778110.3390/metabo13070781Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ DamageMartino Deidda0Antonio Noto1Davide Firinu2Cristina Piras3William Cordeddu4Claudia Depau5Giulia Costanzo6Stefano Del Giacco7Luigi Atzori8Giuseppe Mercuro9Christian Cadeddu Dessalvi10Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, ItalySystemic lupus erythematosus (SLE) is a chronic inflammatory disease, and several studies have suggested possible early RV involvement. Aim of the study was to evaluate the 3D echo parameters of the right ventricle (RV) and the metabolomic profile to correlate both with SLE severity. Forty SLE patients, free of cardiovascular disease, were enrolled and the following 3D parameters were evaluated: the RV ejection fraction (RV-EF), longitudinal strain of the interventricular septum (Septal LS), longitudinal strain of the free wall (Free-LS) and the fractional area change (FAC). In addition, a metabolomic analysis was performed. Direct correlations were observed between TAPSE values and the RV 3D parameters. Then, when splitting the population according to the SDI value, it was found that patients with higher cumulative damage (≥3) had significantly lower FAC, RV-EF, Septal LS, and Free-LS values; the latter three parameters showed a significant correlation with the metabolic profile of the patients. Furthermore, the division based on SDI values identified different metabolic profiles related to the degree of RV dysfunction. The RV dysfunction induced by the chronic inflammatory state present in SLE can be identified early by 3D echocardiography. Its severity seems to be related to systemic organ damage and the results associated with a specific metabolic fingerprint constituted by 2,4-dihydroxybutyric acid, 3,4-dihydroxybutyric acid, citric acid, glucose, glutamine, glycine, linoleic acid, oleic acid, phosphate, urea, and valine.https://www.mdpi.com/2218-1989/13/7/781metabolomics3D echocardiographyglobal longitudinal strainsystemic lupus erythematosus |
| spellingShingle | Martino Deidda Antonio Noto Davide Firinu Cristina Piras William Cordeddu Claudia Depau Giulia Costanzo Stefano Del Giacco Luigi Atzori Giuseppe Mercuro Christian Cadeddu Dessalvi Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage Metabolites metabolomics 3D echocardiography global longitudinal strain systemic lupus erythematosus |
| title | Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage |
| title_full | Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage |
| title_fullStr | Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage |
| title_full_unstemmed | Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage |
| title_short | Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage |
| title_sort | right ventricular subclinical dysfunction in sle patients correlates with metabolomic fingerprint and organ damage |
| topic | metabolomics 3D echocardiography global longitudinal strain systemic lupus erythematosus |
| url | https://www.mdpi.com/2218-1989/13/7/781 |
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