ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway

ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway

Abstract Background Acute myeloid leukemia (AML) is an aggressive and mostly incurable hematological malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently required to improve AML clinical outcomes. 4-Amino-2-trifluoromethyl-phen...

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Bibliographic Details
Main Authors: Yubin Feng, Xiaoxiao Hua, Ruowen Niu, Yan Du, Congjian Shi, Renpeng Zhou, Fei-Hu Chen
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Biological Research
Subjects:
Acute myeloid leukemia
Differentiation
Proliferation
ATPR
ROS
PTEN/PI3K/AKT
Online Access:http://link.springer.com/article/10.1186/s40659-019-0232-9

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