Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina
Abstract Background Venous thromboembolism (VTE) affects approximately 1–2 individuals per 1000 annually and is associated with an increased risk for pulmonary hypertension, postthrombotic syndrome, and recurrent VTE. Objective To determine risk factors, incidence, treatments, and outcomes of VTE th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12769 |
| _version_ | 1797761038433648640 |
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| author | Ibrahim Saber Alys Adamski Maragatha Kuchibhatla Karon Abe Michele Beckman Nimia Reyes Ryan Schulteis Bhavana Pendurthi Singh Andrea Sitlinger Elizabeth H. Thames Thomas L. Ortel |
| author_facet | Ibrahim Saber Alys Adamski Maragatha Kuchibhatla Karon Abe Michele Beckman Nimia Reyes Ryan Schulteis Bhavana Pendurthi Singh Andrea Sitlinger Elizabeth H. Thames Thomas L. Ortel |
| author_sort | Ibrahim Saber |
| collection | DOAJ |
| description | Abstract Background Venous thromboembolism (VTE) affects approximately 1–2 individuals per 1000 annually and is associated with an increased risk for pulmonary hypertension, postthrombotic syndrome, and recurrent VTE. Objective To determine risk factors, incidence, treatments, and outcomes of VTE through a 2‐year surveillance program initiated in Durham County, North Carolina (population approximately 280,000 at time of study). Patients/Methods We performed a retrospective analysis of data actively collected from three hospitals in Durham County during the surveillance period. Results A total of 987 patients were diagnosed with VTE, for an annual rate of 1.76 per 1000 individuals. Hospital‐associated VTE occurred in 167 hospitalized patients (16.9%) and 271 outpatients who were hospitalized within 90 days of diagnosis (27.5%). Annual incidence was 1.98 per 1000 Black individuals compared to 1.25 per 1000 White individuals (p < 0.0001), and Black individuals with VTE were younger than White individuals (p < 0.0001). Common risk factors included active cancer, prolonged immobility, and obesity, and approximately half were still taking anticoagulant therapy 1 year later. A total of 224 patients died by 1 year (28.5% of patients for whom outcomes could be confirmed), and Black patients were more likely to have recurrent VTE than White patients during the first 6 months following initial presentation (9.4% vs. 4.1%, p = 0.01). Conclusions Ongoing surveillance provides an effective strategy to identify patients with VTE and monitor treatment and outcomes. We demonstrated that hospital‐associated VTE continues to be a major contributor to the burden of VTE and confirmed the higher incidence of VTE in Black compared to White individuals. |
| first_indexed | 2024-03-12T19:07:11Z |
| format | Article |
| id | doaj.art-676ddb54bf6f4654813cf7dc41835b41 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T19:07:11Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-676ddb54bf6f4654813cf7dc41835b412023-08-02T06:07:37ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792022-07-0165n/an/a10.1002/rth2.12769Racial differences in venous thromboembolism: A surveillance program in Durham County, North CarolinaIbrahim Saber0Alys Adamski1Maragatha Kuchibhatla2Karon Abe3Michele Beckman4Nimia Reyes5Ryan Schulteis6Bhavana Pendurthi Singh7Andrea Sitlinger8Elizabeth H. Thames9Thomas L. Ortel10Division of Hematology, Department of Medicine Duke University Medical Center Durham North Carolina USACenters for Disease Control and Prevention Atlanta Georgia USADepartment of Biostatistics and Bioinformatics Duke University Durham North Carolina USACenters for Disease Control and Prevention Atlanta Georgia USACenters for Disease Control and Prevention Atlanta Georgia USACenters for Disease Control and Prevention Atlanta Georgia USADurham Veterans' Administration Medical Center Durham North Carolina USALehigh Valley Hospital Pocono East Stroudsburg Pennsylvania USADivision of Hematologic Malignancies and Cellular Therapy, Department of Medicine Duke University Medical Center Durham North Carolina USADivision of Hematology, Department of Medicine Duke University Medical Center Durham North Carolina USADivision of Hematology, Department of Medicine Duke University Medical Center Durham North Carolina USAAbstract Background Venous thromboembolism (VTE) affects approximately 1–2 individuals per 1000 annually and is associated with an increased risk for pulmonary hypertension, postthrombotic syndrome, and recurrent VTE. Objective To determine risk factors, incidence, treatments, and outcomes of VTE through a 2‐year surveillance program initiated in Durham County, North Carolina (population approximately 280,000 at time of study). Patients/Methods We performed a retrospective analysis of data actively collected from three hospitals in Durham County during the surveillance period. Results A total of 987 patients were diagnosed with VTE, for an annual rate of 1.76 per 1000 individuals. Hospital‐associated VTE occurred in 167 hospitalized patients (16.9%) and 271 outpatients who were hospitalized within 90 days of diagnosis (27.5%). Annual incidence was 1.98 per 1000 Black individuals compared to 1.25 per 1000 White individuals (p < 0.0001), and Black individuals with VTE were younger than White individuals (p < 0.0001). Common risk factors included active cancer, prolonged immobility, and obesity, and approximately half were still taking anticoagulant therapy 1 year later. A total of 224 patients died by 1 year (28.5% of patients for whom outcomes could be confirmed), and Black patients were more likely to have recurrent VTE than White patients during the first 6 months following initial presentation (9.4% vs. 4.1%, p = 0.01). Conclusions Ongoing surveillance provides an effective strategy to identify patients with VTE and monitor treatment and outcomes. We demonstrated that hospital‐associated VTE continues to be a major contributor to the burden of VTE and confirmed the higher incidence of VTE in Black compared to White individuals.https://doi.org/10.1002/rth2.12769deep vein thrombosispulmonary embolismracial grouprisk factorsurveillancevenous thromboembolism |
| spellingShingle | Ibrahim Saber Alys Adamski Maragatha Kuchibhatla Karon Abe Michele Beckman Nimia Reyes Ryan Schulteis Bhavana Pendurthi Singh Andrea Sitlinger Elizabeth H. Thames Thomas L. Ortel Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina Research and Practice in Thrombosis and Haemostasis deep vein thrombosis pulmonary embolism racial group risk factor surveillance venous thromboembolism |
| title | Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina |
| title_full | Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina |
| title_fullStr | Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina |
| title_full_unstemmed | Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina |
| title_short | Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina |
| title_sort | racial differences in venous thromboembolism a surveillance program in durham county north carolina |
| topic | deep vein thrombosis pulmonary embolism racial group risk factor surveillance venous thromboembolism |
| url | https://doi.org/10.1002/rth2.12769 |
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