Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid
IntroductionAutism spectrum disorder (ASD) is considered a significant behavioral problem that is characterized by impairment in social interaction and communication. It is believed that some cases of ASD originate in the intrauterine maternal environment. Therefore, we hypothesized that there might...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.998695/full |
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| author | Namareq Widatalla Ahsan Khandoker Chihiro Yoshida Chihiro Yoshida Kana Nakanishi Miyabi Fukase Arisa Suzuki Masatoshi Saito Masatoshi Saito Masatoshi Saito Masatoshi Saito Yoshitaka Kimura Yoshitaka Kimura Yoshitaka Kimura Yoshiyuki Kasahara Yoshiyuki Kasahara Yoshiyuki Kasahara Yoshiyuki Kasahara |
| author_facet | Namareq Widatalla Ahsan Khandoker Chihiro Yoshida Chihiro Yoshida Kana Nakanishi Miyabi Fukase Arisa Suzuki Masatoshi Saito Masatoshi Saito Masatoshi Saito Masatoshi Saito Yoshitaka Kimura Yoshitaka Kimura Yoshitaka Kimura Yoshiyuki Kasahara Yoshiyuki Kasahara Yoshiyuki Kasahara Yoshiyuki Kasahara |
| author_sort | Namareq Widatalla |
| collection | DOAJ |
| description | IntroductionAutism spectrum disorder (ASD) is considered a significant behavioral problem that is characterized by impairment in social interaction and communication. It is believed that some cases of ASD originate in the intrauterine maternal environment. Therefore, we hypothesized that there might be qualitative changes in the interaction between the mother and fetus in ASD during the prenatal period, hence, we investigated the similarity patterns between maternal and fetal heart rate (HR).MethodsIn this study, we first demonstrate the presence and formation of similarities between maternal and fetal RR interval (RRI) collected from typical developmental mice at different embryonic days (EDs), ED13.5, ED15.5, ED17.5, and ED18.5. The similarities were quantified by means of cross-correlation (CC) and magnitude-squared coherence (MSC) analyses. Correlation analysis between the CC coefficients and EDs and between MSC coefficients and EDs showed that the same coefficients increase with EDs, suggesting that similarities between maternal and fetal RRI are associated with typical fetal development. Next, because maternal and fetal similarities were indicative of development, a comparison analysis between the autism mouse model (injected with valproic acid (VPA)), and the control group (injected with saline) was performed for ED15.5 and ED18.5.ResultsThe results of the comparison showed that the CC and MSC coefficients of VPA fetuses were significantly lower than that of the control group. The lower coefficients in VPA-treated mice suggest that they could be one of the features of ASD symptoms. The findings of this study can assist in identifying potential ASD causes during the prenatal period. |
| first_indexed | 2024-04-11T13:52:04Z |
| format | Article |
| id | doaj.art-676e7259b1984b319063935080e8047c |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T13:52:04Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-676e7259b1984b319063935080e8047c2022-12-22T04:20:31ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-11-011310.3389/fpsyt.2022.998695998695Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acidNamareq Widatalla0Ahsan Khandoker1Chihiro Yoshida2Chihiro Yoshida3Kana Nakanishi4Miyabi Fukase5Arisa Suzuki6Masatoshi Saito7Masatoshi Saito8Masatoshi Saito9Masatoshi Saito10Yoshitaka Kimura11Yoshitaka Kimura12Yoshitaka Kimura13Yoshiyuki Kasahara14Yoshiyuki Kasahara15Yoshiyuki Kasahara16Yoshiyuki Kasahara17Next Generation Biological Information Technology, Tohoku University Graduate School of Biomedical Engineering, Sendai, JapanHealthcare Engineering Innovation Center, Department of Biomedical Engineering, Khalifa University, Abu Dhabi, United Arab EmiratesDepartment of Maternal and Fetal Therapeutics, Tohoku University Graduate School of Medicine, Sendai, JapanAdvanced Interdisciplinary Biomedical Engineering, Tohoku University Graduate School of Medicine, Sendai, JapanAdvanced Interdisciplinary Biomedical Engineering, Tohoku University Graduate School of Medicine, Sendai, JapanAdvanced Interdisciplinary Biomedical Engineering, Tohoku University Graduate School of Medicine, Sendai, JapanAdvanced Interdisciplinary Biomedical Engineering, Tohoku University Graduate School of Medicine, Sendai, JapanNext Generation Biological Information Technology, Tohoku University Graduate School of Biomedical Engineering, Sendai, JapanDepartment of Maternal and Fetal Therapeutics, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Maternal and Child Health Care Medical Science, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, JapanNext Generation Biological Information Technology, Tohoku University Graduate School of Biomedical Engineering, Sendai, JapanDepartment of Maternal and Fetal Therapeutics, Tohoku University Graduate School of Medicine, Sendai, JapanAdvanced Interdisciplinary Biomedical Engineering, Tohoku University Graduate School of Medicine, Sendai, JapanNext Generation Biological Information Technology, Tohoku University Graduate School of Biomedical Engineering, Sendai, JapanDepartment of Maternal and Fetal Therapeutics, Tohoku University Graduate School of Medicine, Sendai, JapanAdvanced Interdisciplinary Biomedical Engineering, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Maternal and Child Health Care Medical Science, Tohoku University Graduate School of Medicine, Sendai, JapanIntroductionAutism spectrum disorder (ASD) is considered a significant behavioral problem that is characterized by impairment in social interaction and communication. It is believed that some cases of ASD originate in the intrauterine maternal environment. Therefore, we hypothesized that there might be qualitative changes in the interaction between the mother and fetus in ASD during the prenatal period, hence, we investigated the similarity patterns between maternal and fetal heart rate (HR).MethodsIn this study, we first demonstrate the presence and formation of similarities between maternal and fetal RR interval (RRI) collected from typical developmental mice at different embryonic days (EDs), ED13.5, ED15.5, ED17.5, and ED18.5. The similarities were quantified by means of cross-correlation (CC) and magnitude-squared coherence (MSC) analyses. Correlation analysis between the CC coefficients and EDs and between MSC coefficients and EDs showed that the same coefficients increase with EDs, suggesting that similarities between maternal and fetal RRI are associated with typical fetal development. Next, because maternal and fetal similarities were indicative of development, a comparison analysis between the autism mouse model (injected with valproic acid (VPA)), and the control group (injected with saline) was performed for ED15.5 and ED18.5.ResultsThe results of the comparison showed that the CC and MSC coefficients of VPA fetuses were significantly lower than that of the control group. The lower coefficients in VPA-treated mice suggest that they could be one of the features of ASD symptoms. The findings of this study can assist in identifying potential ASD causes during the prenatal period.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.998695/fullmaternal–fetal RRI similarityfetal mouse developmentfetal programmingautonomic nervous systemautism spectrum disorder |
| spellingShingle | Namareq Widatalla Ahsan Khandoker Chihiro Yoshida Chihiro Yoshida Kana Nakanishi Miyabi Fukase Arisa Suzuki Masatoshi Saito Masatoshi Saito Masatoshi Saito Masatoshi Saito Yoshitaka Kimura Yoshitaka Kimura Yoshitaka Kimura Yoshiyuki Kasahara Yoshiyuki Kasahara Yoshiyuki Kasahara Yoshiyuki Kasahara Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid Frontiers in Psychiatry maternal–fetal RRI similarity fetal mouse development fetal programming autonomic nervous system autism spectrum disorder |
| title | Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid |
| title_full | Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid |
| title_fullStr | Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid |
| title_full_unstemmed | Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid |
| title_short | Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid |
| title_sort | correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid |
| topic | maternal–fetal RRI similarity fetal mouse development fetal programming autonomic nervous system autism spectrum disorder |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.998695/full |
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