Lifting the veil on the keratinocyte contribution to cutaneous nociception
Abstract Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most modulated by keratinocytes. However r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-01-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13238-019-00683-9 |
| _version_ | 1797766580476575744 |
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| author | Matthieu Talagas Nicolas Lebonvallet François Berthod Laurent Misery |
| author_facet | Matthieu Talagas Nicolas Lebonvallet François Berthod Laurent Misery |
| author_sort | Matthieu Talagas |
| collection | DOAJ |
| description | Abstract Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most modulated by keratinocytes. However recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory neurons. To enlighten our understanding of cutaneous nociception, this review highlights recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors, both under healthy and pathological conditions. |
| first_indexed | 2024-03-12T20:27:18Z |
| format | Article |
| id | doaj.art-676f0b24c8134bb5bcdc18a460003597 |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T20:27:18Z |
| publishDate | 2020-01-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-676f0b24c8134bb5bcdc18a4600035972023-08-02T00:23:49ZengOxford University PressProtein & Cell1674-800X1674-80182020-01-0111423925010.1007/s13238-019-00683-9Lifting the veil on the keratinocyte contribution to cutaneous nociceptionMatthieu Talagas0Nicolas Lebonvallet1François Berthod2Laurent Misery3Univ Brest, LIENUniv Brest, LIENLaboratoire d’Organogenèse Expérimentale (LOEX), University of LavalUniv Brest, LIENAbstract Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most modulated by keratinocytes. However recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory neurons. To enlighten our understanding of cutaneous nociception, this review highlights recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors, both under healthy and pathological conditions.https://doi.org/10.1007/s13238-019-00683-9keratinocytenociceptionskinTRPpaininflammation |
| spellingShingle | Matthieu Talagas Nicolas Lebonvallet François Berthod Laurent Misery Lifting the veil on the keratinocyte contribution to cutaneous nociception Protein & Cell keratinocyte nociception skin TRP pain inflammation |
| title | Lifting the veil on the keratinocyte contribution to cutaneous nociception |
| title_full | Lifting the veil on the keratinocyte contribution to cutaneous nociception |
| title_fullStr | Lifting the veil on the keratinocyte contribution to cutaneous nociception |
| title_full_unstemmed | Lifting the veil on the keratinocyte contribution to cutaneous nociception |
| title_short | Lifting the veil on the keratinocyte contribution to cutaneous nociception |
| title_sort | lifting the veil on the keratinocyte contribution to cutaneous nociception |
| topic | keratinocyte nociception skin TRP pain inflammation |
| url | https://doi.org/10.1007/s13238-019-00683-9 |
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