Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles
Zinc oxide nanoparticles (ZnO NPs) are used in various industries such as food additives, cosmetics, and biomedical applications. In this study, we evaluated lung damage over time by three types of ZnO NPs (L-serine, citrate, and pristine) following the regulation of functional groups after a single...
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MDPI AG
2021-12-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/9/12/336 |
| _version_ | 1827669268483801088 |
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| author | Ayoung Jung Sung-Hyun Kim Jun-Young Yang Jayoung Jeong Jong Kwon Lee Jae-Ho Oh Jin Hee Lee |
| author_facet | Ayoung Jung Sung-Hyun Kim Jun-Young Yang Jayoung Jeong Jong Kwon Lee Jae-Ho Oh Jin Hee Lee |
| author_sort | Ayoung Jung |
| collection | DOAJ |
| description | Zinc oxide nanoparticles (ZnO NPs) are used in various industries such as food additives, cosmetics, and biomedical applications. In this study, we evaluated lung damage over time by three types of ZnO NPs (L-serine, citrate, and pristine) following the regulation of functional groups after a single intratracheal instillation to rats. The three types of ZnO NPs showed an acute inflammatory reaction with increased LDH and inflammatory cell infiltration in the alveoli 24 h after administration. Especially in treatment with L-serine, citrate ZnO NPs showed higher acute granulocytic inflammation and total protein induction than the pristine ZnO NPs at 24 h. The acute inflammatory reaction of the lungs recovered on day 30 with bronchoalveolar fibrosis. The concentrations of IL-4, 6, TNF-α, and eotaxin in the bronchoalveolar lavage fluid (BALF) decreased over time, and the levels of these inflammation indicators are consistent with the following inflammatory cell data and acute lung inflammation by ZnO NP. This study suggests that single inhalation exposure to functionalized ZnO NPs may cause acute lung injury with granulocytic inflammation. Although it can recover 30 days after exposure, acute pulmonary inflammation in surface functionalization means that additional studies of exposure limits are needed to protect the workers that produce it. |
| first_indexed | 2024-03-10T03:59:00Z |
| format | Article |
| id | doaj.art-676f0cc803f64051a8bcd4aee8abd14b |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T03:59:00Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-676f0cc803f64051a8bcd4aee8abd14b2023-11-23T10:49:48ZengMDPI AGToxics2305-63042021-12-0191233610.3390/toxics9120336Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide NanoparticlesAyoung Jung0Sung-Hyun Kim1Jun-Young Yang2Jayoung Jeong3Jong Kwon Lee4Jae-Ho Oh5Jin Hee Lee6Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, KoreaDivision of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, KoreaDivision of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, KoreaDivision of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, KoreaDivision of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, KoreaDivision of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, KoreaDivision of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, KoreaZinc oxide nanoparticles (ZnO NPs) are used in various industries such as food additives, cosmetics, and biomedical applications. In this study, we evaluated lung damage over time by three types of ZnO NPs (L-serine, citrate, and pristine) following the regulation of functional groups after a single intratracheal instillation to rats. The three types of ZnO NPs showed an acute inflammatory reaction with increased LDH and inflammatory cell infiltration in the alveoli 24 h after administration. Especially in treatment with L-serine, citrate ZnO NPs showed higher acute granulocytic inflammation and total protein induction than the pristine ZnO NPs at 24 h. The acute inflammatory reaction of the lungs recovered on day 30 with bronchoalveolar fibrosis. The concentrations of IL-4, 6, TNF-α, and eotaxin in the bronchoalveolar lavage fluid (BALF) decreased over time, and the levels of these inflammation indicators are consistent with the following inflammatory cell data and acute lung inflammation by ZnO NP. This study suggests that single inhalation exposure to functionalized ZnO NPs may cause acute lung injury with granulocytic inflammation. Although it can recover 30 days after exposure, acute pulmonary inflammation in surface functionalization means that additional studies of exposure limits are needed to protect the workers that produce it.https://www.mdpi.com/2305-6304/9/12/336nanoparticleszinc oxideintratracheal instillationbronchoalveolar lavageacute inflammation |
| spellingShingle | Ayoung Jung Sung-Hyun Kim Jun-Young Yang Jayoung Jeong Jong Kwon Lee Jae-Ho Oh Jin Hee Lee Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles Toxics nanoparticles zinc oxide intratracheal instillation bronchoalveolar lavage acute inflammation |
| title | Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles |
| title_full | Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles |
| title_fullStr | Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles |
| title_full_unstemmed | Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles |
| title_short | Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles |
| title_sort | effect of pulmonary inflammation by surface functionalization of zinc oxide nanoparticles |
| topic | nanoparticles zinc oxide intratracheal instillation bronchoalveolar lavage acute inflammation |
| url | https://www.mdpi.com/2305-6304/9/12/336 |
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