Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer and has the worst prognosis. In patients with TNBC tumors, the tumor cells have been reported to have mesenchymal features, which help them migrate and invade. Various studies on cancer have revealed the imp...
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MDPI AG
2023-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/6/834 |
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| author | Jorge Alberto Contreras-Rodríguez Jonathan Puente-Rivera Diana Margarita Córdova-Esparza Stephanie I. Nuñez-Olvera Macrina Beatriz Silva-Cázares |
| author_facet | Jorge Alberto Contreras-Rodríguez Jonathan Puente-Rivera Diana Margarita Córdova-Esparza Stephanie I. Nuñez-Olvera Macrina Beatriz Silva-Cázares |
| author_sort | Jorge Alberto Contreras-Rodríguez |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer and has the worst prognosis. In patients with TNBC tumors, the tumor cells have been reported to have mesenchymal features, which help them migrate and invade. Various studies on cancer have revealed the importance of microRNAs (miRNAs) in different biological processes of the cell in that aberrations, in their expression, lead to alterations and deregulations in said processes, giving rise to tumor progression and aggression. In the present work, we determined the miRNAs that are deregulated in the epithelial–mesenchymal transition process in breast cancer. We discovered that 25 miRNAs that regulate mesenchymal genes are overexpressed in patients with TNBC. We found that miRNA targets modulate different processes and pathways, such as apoptosis, FoxO signaling pathways, and Hippo. We also found that the expression level of miR-934 is specific to the molecular subtype of the triple-negative breast cancer and modulates a set of related epithelial–mesenchymal genes. We determined that miR-934 inhibition in TNBC cell lines inhibits the migratory abilities of tumor cells. |
| first_indexed | 2024-03-11T06:47:37Z |
| format | Article |
| id | doaj.art-6770dbe63dcd42d1ac9823773ed70359 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T06:47:37Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6770dbe63dcd42d1ac9823773ed703592023-11-17T10:12:30ZengMDPI AGCells2073-44092023-03-0112683410.3390/cells12060834Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast CancerJorge Alberto Contreras-Rodríguez0Jonathan Puente-Rivera1Diana Margarita Córdova-Esparza2Stephanie I. Nuñez-Olvera3Macrina Beatriz Silva-Cázares4Facultad de Informática, Universidad Autónoma de Querétaro, Querétaro 76010, MexicoDivisión de Investigación, Hospital Juárez de México, Ciudad de México 07760, MexicoFacultad de Informática, Universidad Autónoma de Querétaro, Querétaro 76010, MexicoDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoCoordinación Académica Región Altiplano, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78300, MexicoTriple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer and has the worst prognosis. In patients with TNBC tumors, the tumor cells have been reported to have mesenchymal features, which help them migrate and invade. Various studies on cancer have revealed the importance of microRNAs (miRNAs) in different biological processes of the cell in that aberrations, in their expression, lead to alterations and deregulations in said processes, giving rise to tumor progression and aggression. In the present work, we determined the miRNAs that are deregulated in the epithelial–mesenchymal transition process in breast cancer. We discovered that 25 miRNAs that regulate mesenchymal genes are overexpressed in patients with TNBC. We found that miRNA targets modulate different processes and pathways, such as apoptosis, FoxO signaling pathways, and Hippo. We also found that the expression level of miR-934 is specific to the molecular subtype of the triple-negative breast cancer and modulates a set of related epithelial–mesenchymal genes. We determined that miR-934 inhibition in TNBC cell lines inhibits the migratory abilities of tumor cells.https://www.mdpi.com/2073-4409/12/6/834miR-934–PTEN–EGR2 axismesenchymal–epithelium transitiontriple-negative breast cancermiRNAs |
| spellingShingle | Jorge Alberto Contreras-Rodríguez Jonathan Puente-Rivera Diana Margarita Córdova-Esparza Stephanie I. Nuñez-Olvera Macrina Beatriz Silva-Cázares Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer Cells miR-934–PTEN–EGR2 axis mesenchymal–epithelium transition triple-negative breast cancer miRNAs |
| title | Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer |
| title_full | Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer |
| title_fullStr | Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer |
| title_full_unstemmed | Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer |
| title_short | Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer |
| title_sort | bioinformatic mirna mrnas analysis revels to mir 934 as a potential regulator of the epithelial mesenchymal transition in triple negative breast cancer |
| topic | miR-934–PTEN–EGR2 axis mesenchymal–epithelium transition triple-negative breast cancer miRNAs |
| url | https://www.mdpi.com/2073-4409/12/6/834 |
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