Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study
Introduction Oral health is a fundamental component of well-being, and is closely associated with overall health and quality of life. Oral health may also affect the next generation. The children of mothers with poor oral health are likely to also have poor oral health as they go through life. We ai...
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BMJ Publishing Group
2022-11-01
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Series: | BMJ Open |
Online Access: | https://bmjopen.bmj.com/content/12/11/e066204.full |
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author | Ting Zhang Hua Zhang Ping Ji Chang Chen Xin Jin Richard Saffery Yinyin Xia Pamela Leong Ting-li Han Mei-Ling Zhao Feng-Jing Zhang Wen-Rong Jiang Xin-Yang Yu Peter Mei Hong-Mei Zhang Boris Novakovic Murray Thompson Richard D Cannon |
author_facet | Ting Zhang Hua Zhang Ping Ji Chang Chen Xin Jin Richard Saffery Yinyin Xia Pamela Leong Ting-li Han Mei-Ling Zhao Feng-Jing Zhang Wen-Rong Jiang Xin-Yang Yu Peter Mei Hong-Mei Zhang Boris Novakovic Murray Thompson Richard D Cannon |
author_sort | Ting Zhang |
collection | DOAJ |
description | Introduction Oral health is a fundamental component of well-being, and is closely associated with overall health and quality of life. Oral health may also affect the next generation. The children of mothers with poor oral health are likely to also have poor oral health as they go through life. We aim to investigate associations between maternal oral health and general health, pregnancy outcomes, offspring oral health and offspring general health.Methods and analysis The Lifetime Impact of Oral Health study is a prospective, observational cohort study being done at a single centre in Chongqing, China. A total of 1000 pregnant women will be recruited in their first trimester (11–14 weeks gestation). After obtaining informed consent, general and oral health assessments will be undertaken. Maternal lifestyle, demographic data and biospecimens (blood, hair, urine, nail clippings, saliva, dental plaque, buccal, vaginal and anal swabs) will be collected. Pregnancy outcomes will be recorded at the time of delivery. Cord blood and placenta samples will be collected. The offspring will be followed up for general and oral health examinations, neurodevelopmental assessments and biospecimen (dental plaque, saliva, buccal swabs, exfoliated primary dentition, urine, hair, nail clippings) collection until they are 15 years old. Biological samples will undergo comprehensive metabolomic, microbiome and epigenome analyses. Associations between maternal oral health and general health, pregnancy outcomes, offspring oral health and offspring general health will be investigated and the underlying mechanisms explored.Ethics and dissemination This project has been approved by the Research Ethics Committee of the Affiliated Hospital of Stomatology of Chongqing Medical University (CQHS-REC-2021 LSNo.23). Participants will be required to provide informed consent to participate in the study. Dissemination of findings will take the form of publications in peer-reviewed journals and presentations at national and international conferences.Trial registration number ChiCTR2100046898. |
first_indexed | 2024-04-12T05:54:04Z |
format | Article |
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institution | Directory Open Access Journal |
issn | 2044-6055 |
language | English |
last_indexed | 2024-04-12T05:54:04Z |
publishDate | 2022-11-01 |
publisher | BMJ Publishing Group |
record_format | Article |
series | BMJ Open |
spelling | doaj.art-6772c942e5484d93964f9325d6c766492022-12-22T03:45:12ZengBMJ Publishing GroupBMJ Open2044-60552022-11-01121110.1136/bmjopen-2022-066204Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort studyTing Zhang0Hua Zhang1Ping Ji2Chang Chen3Xin Jin4Richard Saffery5Yinyin Xia6Pamela Leong7Ting-li Han8Mei-Ling Zhao9Feng-Jing Zhang10Wen-Rong Jiang11Xin-Yang Yu12Peter Mei13Hong-Mei Zhang14Boris Novakovic15Murray Thompson16Richard D Cannon171 Department of Biomedical Engineering, University of Houston, Houston, Texas, USA2 Chongqing Health Center for Women and Children, Chongqing, China1 Clinical Research Institute, Shenzhen-Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Public Health, Shenzhen Kangning Hospital, Shenzhen, Guangdong, China2 Neurosurgery, Austin Health, Heidelberg, Victoria, Australia15 Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Parkville, Victoria, Australia2 School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, China4 Cancer, Disease and Developmental Epigenetics, Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne, Victoria, Australia9 Liggins Institute, University of Auckland, Auckland, New ZealandStomatological Hospital of Chongqing Medical University, Chongqing, ChinaStomatological Hospital of Chongqing Medical University, Chongqing, ChinaStomatological Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOral Sciences, University of Otago, Dunedin, New ZealandStomatological Hospital of Chongqing Medical University, Chongqing, ChinaMurdoch Children’s Research Institute, Parkville, Victoria, AustraliaSir John Walsh Research Institute, University of Otago, Dunedin, UKOral Sciences, University of Otago, Dunedin, New ZealandIntroduction Oral health is a fundamental component of well-being, and is closely associated with overall health and quality of life. Oral health may also affect the next generation. The children of mothers with poor oral health are likely to also have poor oral health as they go through life. We aim to investigate associations between maternal oral health and general health, pregnancy outcomes, offspring oral health and offspring general health.Methods and analysis The Lifetime Impact of Oral Health study is a prospective, observational cohort study being done at a single centre in Chongqing, China. A total of 1000 pregnant women will be recruited in their first trimester (11–14 weeks gestation). After obtaining informed consent, general and oral health assessments will be undertaken. Maternal lifestyle, demographic data and biospecimens (blood, hair, urine, nail clippings, saliva, dental plaque, buccal, vaginal and anal swabs) will be collected. Pregnancy outcomes will be recorded at the time of delivery. Cord blood and placenta samples will be collected. The offspring will be followed up for general and oral health examinations, neurodevelopmental assessments and biospecimen (dental plaque, saliva, buccal swabs, exfoliated primary dentition, urine, hair, nail clippings) collection until they are 15 years old. Biological samples will undergo comprehensive metabolomic, microbiome and epigenome analyses. Associations between maternal oral health and general health, pregnancy outcomes, offspring oral health and offspring general health will be investigated and the underlying mechanisms explored.Ethics and dissemination This project has been approved by the Research Ethics Committee of the Affiliated Hospital of Stomatology of Chongqing Medical University (CQHS-REC-2021 LSNo.23). Participants will be required to provide informed consent to participate in the study. Dissemination of findings will take the form of publications in peer-reviewed journals and presentations at national and international conferences.Trial registration number ChiCTR2100046898.https://bmjopen.bmj.com/content/12/11/e066204.full |
spellingShingle | Ting Zhang Hua Zhang Ping Ji Chang Chen Xin Jin Richard Saffery Yinyin Xia Pamela Leong Ting-li Han Mei-Ling Zhao Feng-Jing Zhang Wen-Rong Jiang Xin-Yang Yu Peter Mei Hong-Mei Zhang Boris Novakovic Murray Thompson Richard D Cannon Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study BMJ Open |
title | Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study |
title_full | Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study |
title_fullStr | Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study |
title_full_unstemmed | Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study |
title_short | Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study |
title_sort | investigating the impact of oral health on pregnancy and offspring outcomes protocol for the lifetime impact of oral health liora cohort study |
url | https://bmjopen.bmj.com/content/12/11/e066204.full |
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