<b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475
To investigate the effect of chronic moderate exercise on male reproductive tract of Wistar rats submitted to a single dose of cyclophosphamide (CP). Animals were submitted to swimming exercise during 21 days or maintained at sedentary state. Trained (TCP) and sedentary (SCP) groups received a singl...
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Maringá
2012-08-01
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| Series: | Acta Scientiarum: Biological Sciences |
| Subjects: | |
| Online Access: | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/12475 |
| _version_ | 1818247205652267008 |
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| author | Solange de Paula Ramos Karla Fabiana Goessler Roberto Jose Ruiz Osny Ferrari Marcos Doederlein Polito Maria José Sparça Salles |
| author_facet | Solange de Paula Ramos Karla Fabiana Goessler Roberto Jose Ruiz Osny Ferrari Marcos Doederlein Polito Maria José Sparça Salles |
| author_sort | Solange de Paula Ramos |
| collection | DOAJ |
| description | To investigate the effect of chronic moderate exercise on male reproductive tract of Wistar rats submitted to a single dose of cyclophosphamide (CP). Animals were submitted to swimming exercise during 21 days or maintained at sedentary state. Trained (TCP) and sedentary (SCP) groups received a single dose of CP (200 mg kg-1, i.p.). Trained (TCo) and sedentary (SCo) control animals received sterile PBS. Animals were killed after one week and testis, epidydimis and seminal vesicle contend were weighted. Testis were embebbed in parafim and stained with hemotaxilin and eosin. Fifty seminiferous tubules of each animal were analyzed by Johnsen score. Mean Sertoli cells counts per tubule and Leydig cells counts per area were evaluated. CP treatment impairs body weight gain in trained and sedentary animals. Liver and seminal vesicle contend were reduced only in SCo group. SCP animals presented decreased Johnsen scores, indicating a slight toxicity over germinative cells, whereas trained (TCo and TCP) animals presented increased Johnsen scores. Training increased Sertoli cell counts and prevented their loss in TCP group. Leydig cells counts were increased in trained animals, but decreased in CP treated ones (TCP). We conclude that exercise have some protective effect on male reproductive tract submitted to a single dose of CP.
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| first_indexed | 2024-12-12T15:01:00Z |
| format | Article |
| id | doaj.art-67735606261c4158bf9b8e684548c0ad |
| institution | Directory Open Access Journal |
| issn | 1679-9283 1807-863X |
| language | English |
| last_indexed | 2024-12-12T15:01:00Z |
| publishDate | 2012-08-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum: Biological Sciences |
| spelling | doaj.art-67735606261c4158bf9b8e684548c0ad2022-12-22T00:20:48ZengUniversidade Estadual de MaringáActa Scientiarum: Biological Sciences1679-92831807-863X2012-08-0135110.4025/actascibiolsci.v35i1.12475<b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475Solange de Paula Ramos0Karla Fabiana Goessler1Roberto Jose Ruiz2Osny Ferrari3Marcos Doederlein Polito4Maria José Sparça Salles5Universidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaTo investigate the effect of chronic moderate exercise on male reproductive tract of Wistar rats submitted to a single dose of cyclophosphamide (CP). Animals were submitted to swimming exercise during 21 days or maintained at sedentary state. Trained (TCP) and sedentary (SCP) groups received a single dose of CP (200 mg kg-1, i.p.). Trained (TCo) and sedentary (SCo) control animals received sterile PBS. Animals were killed after one week and testis, epidydimis and seminal vesicle contend were weighted. Testis were embebbed in parafim and stained with hemotaxilin and eosin. Fifty seminiferous tubules of each animal were analyzed by Johnsen score. Mean Sertoli cells counts per tubule and Leydig cells counts per area were evaluated. CP treatment impairs body weight gain in trained and sedentary animals. Liver and seminal vesicle contend were reduced only in SCo group. SCP animals presented decreased Johnsen scores, indicating a slight toxicity over germinative cells, whereas trained (TCo and TCP) animals presented increased Johnsen scores. Training increased Sertoli cell counts and prevented their loss in TCP group. Leydig cells counts were increased in trained animals, but decreased in CP treated ones (TCP). We conclude that exercise have some protective effect on male reproductive tract submitted to a single dose of CP. https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/12475cyclophosphamideexercisereproductive tract |
| spellingShingle | Solange de Paula Ramos Karla Fabiana Goessler Roberto Jose Ruiz Osny Ferrari Marcos Doederlein Polito Maria José Sparça Salles <b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475 Acta Scientiarum: Biological Sciences cyclophosphamide exercise reproductive tract |
| title | <b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475 |
| title_full | <b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475 |
| title_fullStr | <b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475 |
| title_full_unstemmed | <b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475 |
| title_short | <b>Exercise protects rat testis from cyclophosphamide-induced damage</b> - doi: 10.4025/actascibiolsci.v35i1.12475 |
| title_sort | b exercise protects rat testis from cyclophosphamide induced damage b doi 10 4025 actascibiolsci v35i1 12475 |
| topic | cyclophosphamide exercise reproductive tract |
| url | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/12475 |
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