Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach
The application of physiologically based pharmacokinetic models to nanoparticles is still very restricted and challenging, owing to the complicated in vivo transport mechanisms involving nanoparticles, including phagocytosis, enhanced permeability and retention effects, cellular recognition, and int...
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/5/1271 |
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| author | Lei Li Haisheng He Sifang Jiang Jianping Qi Yi Lu Ning Ding Hai-Shu Lin Wei Wu Xiaoqiang Xiang |
| author_facet | Lei Li Haisheng He Sifang Jiang Jianping Qi Yi Lu Ning Ding Hai-Shu Lin Wei Wu Xiaoqiang Xiang |
| author_sort | Lei Li |
| collection | DOAJ |
| description | The application of physiologically based pharmacokinetic models to nanoparticles is still very restricted and challenging, owing to the complicated in vivo transport mechanisms involving nanoparticles, including phagocytosis, enhanced permeability and retention effects, cellular recognition, and internalisation, enzymatic degradation, lymphatic transport, and changes in physical properties. In our study, five nanoparticle formulations were synthesised using polycaprolactone as a framework material and methoxy poly (ethylene glycol)-poly(ε-caprolactone) as a long-circulating decorating material, as well as types of environmentally responsive near-infrared aza-boron-dipyrromethene dyes. According to quantification data and direct visualisation involving specific organs, a phagocytosis physiologically based pharmacokinetic model was developed to describe the dynamics of nanoparticles within and between organs in mice, considering cellular mechanisms involving phagocytosis and enhanced permeability and retention effects. Our results offer a better understanding of the in vivo fate of polymeric nanoparticles. |
| first_indexed | 2024-03-09T00:29:24Z |
| format | Article |
| id | doaj.art-6777dfb550094769ba396db4f9e85e66 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T00:29:24Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6777dfb550094769ba396db4f9e85e662023-12-11T18:36:31ZengMDPI AGMolecules1420-30492021-02-01265127110.3390/molecules26051271Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling ApproachLei Li0Haisheng He1Sifang Jiang2Jianping Qi3Yi Lu4Ning Ding5Hai-Shu Lin6Wei Wu7Xiaoqiang Xiang8Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, ChinaWest China School of Pharmacy, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, ChinaCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, ChinaKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, ChinaDepartment of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, ChinaThe application of physiologically based pharmacokinetic models to nanoparticles is still very restricted and challenging, owing to the complicated in vivo transport mechanisms involving nanoparticles, including phagocytosis, enhanced permeability and retention effects, cellular recognition, and internalisation, enzymatic degradation, lymphatic transport, and changes in physical properties. In our study, five nanoparticle formulations were synthesised using polycaprolactone as a framework material and methoxy poly (ethylene glycol)-poly(ε-caprolactone) as a long-circulating decorating material, as well as types of environmentally responsive near-infrared aza-boron-dipyrromethene dyes. According to quantification data and direct visualisation involving specific organs, a phagocytosis physiologically based pharmacokinetic model was developed to describe the dynamics of nanoparticles within and between organs in mice, considering cellular mechanisms involving phagocytosis and enhanced permeability and retention effects. Our results offer a better understanding of the in vivo fate of polymeric nanoparticles.https://www.mdpi.com/1420-3049/26/5/1271physiologically based pharmacokinetic modelmethoxy poly (ethylene glycol)-poly (ε-caprolactone)nanoparticlesphagocytosisbiodistribution |
| spellingShingle | Lei Li Haisheng He Sifang Jiang Jianping Qi Yi Lu Ning Ding Hai-Shu Lin Wei Wu Xiaoqiang Xiang Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach Molecules physiologically based pharmacokinetic model methoxy poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles phagocytosis biodistribution |
| title | Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach |
| title_full | Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach |
| title_fullStr | Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach |
| title_full_unstemmed | Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach |
| title_short | Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach |
| title_sort | simulation of the in vivo fate of polymeric nanoparticles traced by environment responsive near infrared dye a physiologically based pharmacokinetic modelling approach |
| topic | physiologically based pharmacokinetic model methoxy poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles phagocytosis biodistribution |
| url | https://www.mdpi.com/1420-3049/26/5/1271 |
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