Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review
Background and Purpose: The blood-brain barrier (BBB), a critical interface of specialized endothelial cells, plays a pivotal role in regulating molecular and ion transport between the central nervous system (CNS) and systemic circulation. Experimental Approach: This review aims to delve into the i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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International Association of Physical Chemists (IAPC)
2023-10-01
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| Series: | ADMET and DMPK |
| Subjects: | |
| Online Access: | https://pub.iapchem.org/ojs/index.php/admet/article/view/2043 |
| _version_ | 1797629804184338432 |
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| author | Mangesh Kulkarni Krishi Patel Ayush Patel Swayamprakash Patel Jagruti Desai Mehul Patel Umang Shah Ashish Patel Nilay Solanki |
| author_facet | Mangesh Kulkarni Krishi Patel Ayush Patel Swayamprakash Patel Jagruti Desai Mehul Patel Umang Shah Ashish Patel Nilay Solanki |
| author_sort | Mangesh Kulkarni |
| collection | DOAJ |
| description |
Background and Purpose: The blood-brain barrier (BBB), a critical interface of specialized endothelial cells, plays a pivotal role in regulating molecular and ion transport between the central nervous system (CNS) and systemic circulation. Experimental Approach: This review aims to delve into the intricate architecture and functions of the BBB while addressing challenges associated with delivering therapeutics to the brain. Historical milestones and contemporary insights underscore the BBB's significance in protecting the CNS. Key Results: Innovative approaches for enhanced drug transport include intranasal delivery exploiting olfactory and trigeminal pathways, as well as techniques like temporary BBB opening through chemicals, receptors, or focused ultrasound. These avenues hold the potential to reshape conventional drug delivery paradigms and address the limitations posed by the BBB's selectivity. Conclusion: This review underscores the vital role of the BBB in maintaining CNS health and emphasizes the importance of effective drug delivery through this barrier. Nanoparticles emerge as promising candidates to overcome BBB limitations and potentially revolutionize the treatment of CNS disorders. As research progresses, the application of nanomaterials shows immense potential for advancing neurological therapeutics, albeit with careful consideration of safety aspects.
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| first_indexed | 2024-03-11T10:58:13Z |
| format | Article |
| id | doaj.art-677971b87243478d842f98fc574bb81c |
| institution | Directory Open Access Journal |
| issn | 1848-7718 |
| language | English |
| last_indexed | 2024-03-11T10:58:13Z |
| publishDate | 2023-10-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | ADMET and DMPK |
| spelling | doaj.art-677971b87243478d842f98fc574bb81c2023-11-13T00:55:07ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182023-10-0110.5599/admet.2043Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive reviewMangesh Kulkarni0Krishi Patel1Ayush Patel2Swayamprakash Patel3Jagruti Desai4Mehul Patel5Umang Shah6Ashish Patel7Nilay Solanki8Department of Pharmaceutical Technology; L J Institute of Pharmacy; L J University; Opp. Kataria Motors; Sarkhej-Gandhinagar Highway-382210Department of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, IndiaDepartment of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, IndiaDepartment of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, IndiaDepartment of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, IndiaDepartment of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, IndiaDepartment of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, IndiaDepartment of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, IndiaDepartment of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, India Background and Purpose: The blood-brain barrier (BBB), a critical interface of specialized endothelial cells, plays a pivotal role in regulating molecular and ion transport between the central nervous system (CNS) and systemic circulation. Experimental Approach: This review aims to delve into the intricate architecture and functions of the BBB while addressing challenges associated with delivering therapeutics to the brain. Historical milestones and contemporary insights underscore the BBB's significance in protecting the CNS. Key Results: Innovative approaches for enhanced drug transport include intranasal delivery exploiting olfactory and trigeminal pathways, as well as techniques like temporary BBB opening through chemicals, receptors, or focused ultrasound. These avenues hold the potential to reshape conventional drug delivery paradigms and address the limitations posed by the BBB's selectivity. Conclusion: This review underscores the vital role of the BBB in maintaining CNS health and emphasizes the importance of effective drug delivery through this barrier. Nanoparticles emerge as promising candidates to overcome BBB limitations and potentially revolutionize the treatment of CNS disorders. As research progresses, the application of nanomaterials shows immense potential for advancing neurological therapeutics, albeit with careful consideration of safety aspects. https://pub.iapchem.org/ojs/index.php/admet/article/view/2043CNSdrug deliverynanoparticleliposomesdendrimersafety and regulation |
| spellingShingle | Mangesh Kulkarni Krishi Patel Ayush Patel Swayamprakash Patel Jagruti Desai Mehul Patel Umang Shah Ashish Patel Nilay Solanki Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review ADMET and DMPK CNS drug delivery nanoparticle liposomes dendrimer safety and regulation |
| title | Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review |
| title_full | Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review |
| title_fullStr | Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review |
| title_full_unstemmed | Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review |
| title_short | Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review |
| title_sort | nanomaterials as drug delivery agents for overcoming the blood brain barrier a comprehensive review |
| topic | CNS drug delivery nanoparticle liposomes dendrimer safety and regulation |
| url | https://pub.iapchem.org/ojs/index.php/admet/article/view/2043 |
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