Roles of the Drosophila SK channel (dSK) in courtship memory.
A role for SK channels in synaptic plasticity has been very well-characterized. However, in the absence of simple genetic animal models, their role in behavioral memory remains elusive. Here, we take advantage of Drosophila melanogaster with its single SK gene (dSK) and well-established courtship me...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3324495?pdf=render |
| _version_ | 1828532499375980544 |
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| author | Ahmad N Abou Tayoun Claudio Pikielny Patrick J Dolph |
| author_facet | Ahmad N Abou Tayoun Claudio Pikielny Patrick J Dolph |
| author_sort | Ahmad N Abou Tayoun |
| collection | DOAJ |
| description | A role for SK channels in synaptic plasticity has been very well-characterized. However, in the absence of simple genetic animal models, their role in behavioral memory remains elusive. Here, we take advantage of Drosophila melanogaster with its single SK gene (dSK) and well-established courtship memory assay to investigate the contribution of this channel to memory. Using two independent dSK alleles, a null mutation and a dominant negative subunit, we show that while dSK negatively regulates the acquisition of short-term memory 30 min after a short training session, it is required for normal long-term memory 24 h after extended training. These findings highlight important functions for dSK in courtship memory and suggest that SK channels can mediate multiple forms of behavioral plasticity. |
| first_indexed | 2024-12-11T22:53:55Z |
| format | Article |
| id | doaj.art-677bf50e760b4780a8192f2b5a4594d8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:53:55Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-677bf50e760b4780a8192f2b5a4594d82022-12-22T00:47:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3466510.1371/journal.pone.0034665Roles of the Drosophila SK channel (dSK) in courtship memory.Ahmad N Abou TayounClaudio PikielnyPatrick J DolphA role for SK channels in synaptic plasticity has been very well-characterized. However, in the absence of simple genetic animal models, their role in behavioral memory remains elusive. Here, we take advantage of Drosophila melanogaster with its single SK gene (dSK) and well-established courtship memory assay to investigate the contribution of this channel to memory. Using two independent dSK alleles, a null mutation and a dominant negative subunit, we show that while dSK negatively regulates the acquisition of short-term memory 30 min after a short training session, it is required for normal long-term memory 24 h after extended training. These findings highlight important functions for dSK in courtship memory and suggest that SK channels can mediate multiple forms of behavioral plasticity.http://europepmc.org/articles/PMC3324495?pdf=render |
| spellingShingle | Ahmad N Abou Tayoun Claudio Pikielny Patrick J Dolph Roles of the Drosophila SK channel (dSK) in courtship memory. PLoS ONE |
| title | Roles of the Drosophila SK channel (dSK) in courtship memory. |
| title_full | Roles of the Drosophila SK channel (dSK) in courtship memory. |
| title_fullStr | Roles of the Drosophila SK channel (dSK) in courtship memory. |
| title_full_unstemmed | Roles of the Drosophila SK channel (dSK) in courtship memory. |
| title_short | Roles of the Drosophila SK channel (dSK) in courtship memory. |
| title_sort | roles of the drosophila sk channel dsk in courtship memory |
| url | http://europepmc.org/articles/PMC3324495?pdf=render |
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