Roles of CD4+ T cells as mediators of antitumor immunity
It has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells. However, in several experimental models as well as in cancer patients, it has been shown that...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.972021/full |
| _version_ | 1811273982721130496 |
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| author | Dmitriy S. Kravtsov Amy K. Erbe Paul M. Sondel Paul M. Sondel Alexander L. Rakhmilevich |
| author_facet | Dmitriy S. Kravtsov Amy K. Erbe Paul M. Sondel Paul M. Sondel Alexander L. Rakhmilevich |
| author_sort | Dmitriy S. Kravtsov |
| collection | DOAJ |
| description | It has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells. However, in several experimental models as well as in cancer patients, it has been shown that CD4+ T cells can also mediate antitumor immunity either directly by killing tumor cells or indirectly by activating innate immune cells or by reducing tumor angiogenesis. In this review, we discuss the growing evidence of this underappreciated role of CD4+ T cells as mediators of antitumor immunity. |
| first_indexed | 2024-04-12T23:09:23Z |
| format | Article |
| id | doaj.art-677ce5979c3e4b038c33a5c8727ae019 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T23:09:23Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-677ce5979c3e4b038c33a5c8727ae0192022-12-22T03:12:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.972021972021Roles of CD4+ T cells as mediators of antitumor immunityDmitriy S. Kravtsov0Amy K. Erbe1Paul M. Sondel2Paul M. Sondel3Alexander L. Rakhmilevich4Department of Human Oncology, University of Wisconsin, Madison, WI, United StatesDepartment of Human Oncology, University of Wisconsin, Madison, WI, United StatesDepartment of Human Oncology, University of Wisconsin, Madison, WI, United StatesDepartment of Pediatrics, University of Wisconsin, Madison, WI, United StatesDepartment of Human Oncology, University of Wisconsin, Madison, WI, United StatesIt has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells. However, in several experimental models as well as in cancer patients, it has been shown that CD4+ T cells can also mediate antitumor immunity either directly by killing tumor cells or indirectly by activating innate immune cells or by reducing tumor angiogenesis. In this review, we discuss the growing evidence of this underappreciated role of CD4+ T cells as mediators of antitumor immunity.https://www.frontiersin.org/articles/10.3389/fimmu.2022.972021/fullCD4+ T cellsadoptive cell therapyMHCcytotoxicityimmunotherapy |
| spellingShingle | Dmitriy S. Kravtsov Amy K. Erbe Paul M. Sondel Paul M. Sondel Alexander L. Rakhmilevich Roles of CD4+ T cells as mediators of antitumor immunity Frontiers in Immunology CD4+ T cells adoptive cell therapy MHC cytotoxicity immunotherapy |
| title | Roles of CD4+ T cells as mediators of antitumor immunity |
| title_full | Roles of CD4+ T cells as mediators of antitumor immunity |
| title_fullStr | Roles of CD4+ T cells as mediators of antitumor immunity |
| title_full_unstemmed | Roles of CD4+ T cells as mediators of antitumor immunity |
| title_short | Roles of CD4+ T cells as mediators of antitumor immunity |
| title_sort | roles of cd4 t cells as mediators of antitumor immunity |
| topic | CD4+ T cells adoptive cell therapy MHC cytotoxicity immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.972021/full |
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