Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production

Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production

ABSTRACT Human respiratory syncytial virus (HRSV) envelope glycoproteins traffic to assembly sites through the secretory pathway, while nonglycosylated proteins M and N are present in HRSV inclusion bodies but must reach the plasma membrane, where HRSV assembly happens. Little is known about how non...

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Bibliographic Details
Main Authors: Ricardo S. Cardoso, Lucas Alves Tavares, Bruna Lais S. Jesus, Miria F. Criado, Andreia Nogueira de Carvalho, Juliano de Paula Souza, Sukhmani Bedi, Marcos Michel de Souza, Maria Lucia Silva, Guilherme Pauperio Lanfredi, Brenda Cristina Vitti, Orlando Bonito Scudero, Vitor Marcel Faça, Akira Ono, Armando M. Ventura, Luis Lamberti P. daSilva, Eurico Arruda
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
human respiratory syncytial virus
paramyxovirus
protein trafficking
virus-host interactions
Online Access:https://journals.asm.org/doi/10.1128/mBio.01869-20

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