Persistent, Asymptomatic Colonization with Candida is Associated with Elevated Frequencies of Highly Activated Cervical Th17-Like Cells and Related Cytokines in the Reproductive Tract of South African Adolescents

Persistent, Asymptomatic Colonization with Candida is Associated with Elevated Frequencies of Highly Activated Cervical Th17-Like Cells and Related Cytokines in the Reproductive Tract of South African Adolescents

ABSTRACT Cervicovaginal inflammation, nonoptimal microbiota, T-cell activation, and hormonal contraceptives may increase HIV risk, yet associations between these factors and subclinical Candida colonization or hyphae are unknown. We collected cervicovaginal samples from 94 South African adolescents,...

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Bibliographic Details
Main Authors: Anna-Ursula Happel, Melanie Gasper, Christina Balle, Iyaloo Konstantinus, Hoyam Gamieldien, Smritee Dabee, Katherine Gill, Linda-Gail Bekker, Jo-Ann S. Passmore, Heather B. Jaspan
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
vaginal candidiasis
Sub-Saharan Africa
genital inflammation
HIV target cells
mucosal immunity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01626-21

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