Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients
Background: Ischemic stroke (IS) is a prevalent disease causing a body disability, the third leading cause of death in Taiwan. It shows that the level of intercellular adhesion molecular-1 (ICAM-1) in IS patients is higher than control subjects. Objective: This study is to investigate the possible a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
|
| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=3;spage=380;epage=383;aulast=Lu |
| _version_ | 1811270977569423360 |
|---|---|
| author | Ching-Hsiang Lu Chiao-Wen Hwang Nan-Fu Chen Wen-Sheng Liu Wen-Tung Wu |
| author_facet | Ching-Hsiang Lu Chiao-Wen Hwang Nan-Fu Chen Wen-Sheng Liu Wen-Tung Wu |
| author_sort | Ching-Hsiang Lu |
| collection | DOAJ |
| description | Background: Ischemic stroke (IS) is a prevalent disease causing a body disability, the third leading cause of death in Taiwan. It shows that the level of intercellular adhesion molecular-1 (ICAM-1) in IS patients is higher than control subjects. Objective: This study is to investigate the possible association of ICAM-1 (G1548A) polymorphism in IS patients. Materials and Methods: A total of 646 subjects were enrolled in this study, including 312 IS patients, and 334 controls without a history of symptomatic IS. The ICAM-1 (G1548A) polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism. Clinical factors were also determined. Results: The frequencies of the ICAM-1 (G1548A) polymorphism for G/G, G/A, and A/A were 74.8%, 23.9%, and 0.3%, respectively, in healthy controls, and 62.8%, 32.1%, and 5.1%, respectively, in patients. The frequency of the ICAM-1 (G1548A) A allele (21.2% versus 13.2%, respectively; P = 0.007) and the carriers of the ICAM-1 (G1548A) A allele (37.2% versus 25.2%; P = 0.019, OR 1.76, 95% CI 1.1-2.83) are great in IS patients compared with healthy controls. There is a higher risk of IS associated with homozygosity for the ICAM-1 (G1548A) A allele (AA genotype) compared with the control population (5.1% vs. 0.3%, respectively, P = 0.04; OR 5.1, 95% CI 1.19-21.66). We also observed both hypertension and diabetes has shown a positive association with IS. Conclusions: The ICAM-1 (G1548A) polymorphism was associated with independent risk factor for the development of IS. |
| first_indexed | 2024-04-12T22:13:01Z |
| format | Article |
| id | doaj.art-67804022452e40018682e266528e7ffc |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-04-12T22:13:01Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-67804022452e40018682e266528e7ffc2022-12-22T03:14:41ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492013-01-0116338038310.4103/0972-2327.116950Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patientsChing-Hsiang LuChiao-Wen HwangNan-Fu ChenWen-Sheng LiuWen-Tung WuBackground: Ischemic stroke (IS) is a prevalent disease causing a body disability, the third leading cause of death in Taiwan. It shows that the level of intercellular adhesion molecular-1 (ICAM-1) in IS patients is higher than control subjects. Objective: This study is to investigate the possible association of ICAM-1 (G1548A) polymorphism in IS patients. Materials and Methods: A total of 646 subjects were enrolled in this study, including 312 IS patients, and 334 controls without a history of symptomatic IS. The ICAM-1 (G1548A) polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism. Clinical factors were also determined. Results: The frequencies of the ICAM-1 (G1548A) polymorphism for G/G, G/A, and A/A were 74.8%, 23.9%, and 0.3%, respectively, in healthy controls, and 62.8%, 32.1%, and 5.1%, respectively, in patients. The frequency of the ICAM-1 (G1548A) A allele (21.2% versus 13.2%, respectively; P = 0.007) and the carriers of the ICAM-1 (G1548A) A allele (37.2% versus 25.2%; P = 0.019, OR 1.76, 95% CI 1.1-2.83) are great in IS patients compared with healthy controls. There is a higher risk of IS associated with homozygosity for the ICAM-1 (G1548A) A allele (AA genotype) compared with the control population (5.1% vs. 0.3%, respectively, P = 0.04; OR 5.1, 95% CI 1.19-21.66). We also observed both hypertension and diabetes has shown a positive association with IS. Conclusions: The ICAM-1 (G1548A) polymorphism was associated with independent risk factor for the development of IS.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=3;spage=380;epage=383;aulast=LuAlleleintercellular adhesion molecular-1ischemic strokepolymorphism |
| spellingShingle | Ching-Hsiang Lu Chiao-Wen Hwang Nan-Fu Chen Wen-Sheng Liu Wen-Tung Wu Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients Annals of Indian Academy of Neurology Allele intercellular adhesion molecular-1 ischemic stroke polymorphism |
| title | Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients |
| title_full | Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients |
| title_fullStr | Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients |
| title_full_unstemmed | Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients |
| title_short | Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients |
| title_sort | association of intercellular adhesion molecular 1 gene polymorphism in ischemic stroke patients |
| topic | Allele intercellular adhesion molecular-1 ischemic stroke polymorphism |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=3;spage=380;epage=383;aulast=Lu |
| work_keys_str_mv | AT chinghsianglu associationofintercellularadhesionmolecular1genepolymorphisminischemicstrokepatients AT chiaowenhwang associationofintercellularadhesionmolecular1genepolymorphisminischemicstrokepatients AT nanfuchen associationofintercellularadhesionmolecular1genepolymorphisminischemicstrokepatients AT wenshengliu associationofintercellularadhesionmolecular1genepolymorphisminischemicstrokepatients AT wentungwu associationofintercellularadhesionmolecular1genepolymorphisminischemicstrokepatients |