Crystal structures of main proteases of SARS-CoV-2 variants bound to a benzothiazole-based inhibitor

Crystal structures of main proteases of SARS-CoV-2 variants bound to a benzothiazole-based inhibitor

Main protease (M <sup>pro</sup>) serves as an indispensable factor in the life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as its constantly emerging variants and is therefore considered an attractive target for antiviral drug development. Benzothiazole-...

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Bibliographic Details
Main Authors: Luo Jiqing, Wang Weiwei, Jiang Haihai, Li Wenwen, Zeng Pei, Wang Jie, Zhou Xuelan, Zou Xiaofang, Chen Shenghui, Wang Qisheng, Zhang Jin, Li Jian
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-06-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
SARS-CoV-2
variant
main protease
inhibitor
benzothiazole
YH-53
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023053

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