The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system
Quantitative proteins analysis was carried out in the hypothalamus of zebrafish following dietary exposure to the legacy pesticide dieldrin. Data were collected using iTRAQ labeling methodology and data were acquired using a hybrid quadrupole Orbitrap (Q Exactive) MS system (Thermo Fisher Scientific...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917300847 |
| _version_ | 1818178945399390208 |
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| author | Andrew M. Cowie Kathleena I. Sarty Angella Mercer Jin Koh Karen A. Kidd Christopher J. Martyniuk |
| author_facet | Andrew M. Cowie Kathleena I. Sarty Angella Mercer Jin Koh Karen A. Kidd Christopher J. Martyniuk |
| author_sort | Andrew M. Cowie |
| collection | DOAJ |
| description | Quantitative proteins analysis was carried out in the hypothalamus of zebrafish following dietary exposure to the legacy pesticide dieldrin. Data were collected using iTRAQ labeling methodology and data were acquired using a hybrid quadrupole Orbitrap (Q Exactive) MS system (Thermo Fisher Scientific, Bremen, Germany). There were 3941 proteins identified in the hypothalamus of zebrafish, and these proteins comprised 23 unique expression patterns for proteins based on the three doses of dieldrin. There were 226 proteins that were regulated in one or more doses of dieldrin and 3715 proteins that were not affected. Thus, 5.7% of the proteins detected responded to the treatment. Many proteins that were differentially expressed were those found in, or associated with, the mitochondria. The proteomics data described in this article is associated with a research article, “Transcriptomic and proteomic analysis implicates the immune system and mitochondria as molecular targets of dieldrin in the zebrafish (Danio rerio) central nervous system” (A.M. Cowie, K.I. Sarty, A. Mercer, J. Koh, K.A. Kidd, C.J. Martyniuk, submitted) [1], and serves as a resource for researchers working in the field of pesticide exposures and protein biomarkers. |
| first_indexed | 2024-12-11T20:56:02Z |
| format | Article |
| id | doaj.art-6781f453815f436790ced951094fbeb6 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T20:56:02Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-6781f453815f436790ced951094fbeb62022-12-22T00:51:07ZengElsevierData in Brief2352-34092017-04-0111C62863310.1016/j.dib.2017.03.008The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous systemAndrew M. Cowie0Kathleena I. Sarty1Angella Mercer2Jin Koh3Karen A. Kidd4Christopher J. Martyniuk5Canadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, CanadaCanadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, CanadaCanadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, CanadaInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USACanadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, CanadaCanadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, CanadaQuantitative proteins analysis was carried out in the hypothalamus of zebrafish following dietary exposure to the legacy pesticide dieldrin. Data were collected using iTRAQ labeling methodology and data were acquired using a hybrid quadrupole Orbitrap (Q Exactive) MS system (Thermo Fisher Scientific, Bremen, Germany). There were 3941 proteins identified in the hypothalamus of zebrafish, and these proteins comprised 23 unique expression patterns for proteins based on the three doses of dieldrin. There were 226 proteins that were regulated in one or more doses of dieldrin and 3715 proteins that were not affected. Thus, 5.7% of the proteins detected responded to the treatment. Many proteins that were differentially expressed were those found in, or associated with, the mitochondria. The proteomics data described in this article is associated with a research article, “Transcriptomic and proteomic analysis implicates the immune system and mitochondria as molecular targets of dieldrin in the zebrafish (Danio rerio) central nervous system” (A.M. Cowie, K.I. Sarty, A. Mercer, J. Koh, K.A. Kidd, C.J. Martyniuk, submitted) [1], and serves as a resource for researchers working in the field of pesticide exposures and protein biomarkers.http://www.sciencedirect.com/science/article/pii/S2352340917300847 |
| spellingShingle | Andrew M. Cowie Kathleena I. Sarty Angella Mercer Jin Koh Karen A. Kidd Christopher J. Martyniuk The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system Data in Brief |
| title | The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system |
| title_full | The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system |
| title_fullStr | The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system |
| title_full_unstemmed | The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system |
| title_short | The pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system |
| title_sort | pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917300847 |
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