Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk
Abstract Background Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and type 2 diabetes mellitus. The objective of this study was to elucidate t...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12902-018-0254-2 |
| _version_ | 1818554249861136384 |
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| author | Karunee Kwanbunjan Pornpimol Panprathip Chanchira Phosat Noppanath Chumpathat Naruemon Wechjakwen Somchai Puduang Ratchada Auyyuenyong Ina Henkel Florian J. Schweigert |
| author_facet | Karunee Kwanbunjan Pornpimol Panprathip Chanchira Phosat Noppanath Chumpathat Naruemon Wechjakwen Somchai Puduang Ratchada Auyyuenyong Ina Henkel Florian J. Schweigert |
| author_sort | Karunee Kwanbunjan |
| collection | DOAJ |
| description | Abstract Background Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and type 2 diabetes mellitus. The objective of this study was to elucidate the relationship between RBP4, TTR, triglyceride (TG) and type 2 diabetes risk in rural Thailand. Methods We measured the serum RBP4, TTR, glucose, triglyceride and insulin levels, and glucose tolerance of 167 volunteers from Sung Noen District, Nakhon Ratchasima Province, Thailand. Student’s t-test, Pearson’s correlation and logistic regression analysis were used to evaluate the relationships between RBP4, TTR and type 2 diabetes markers. Results RBP4 and TTR levels, as well as homeostatic model assessment of insulin resistance (HOMA-IR) values, were significantly elevated among subjects with high triglyceride levels (p < 0.01, p < 0.05, p < 0.05, respectively). Triglyceride levels correlated with RBP4 (r = 0.34, p < 0.001) and TTR (r = 0.26, p < 0.01) levels, as well as HOMA-IR values (r = 0.16, p < 0.05). After adjustment for age and gender, the risk of hypertriglyceridemia was 3.7 times greater (95% CI =1.42–9.73, p = 0.008) in the highest RBP4 tertile as compared to the lowest tertile. Similarly, the highest TTR and HOMA-IR tertiles had greater risk of hypertriglyceridemia at 3.5 (95% CI = 1.30–9.20, p = 0.01) and 3.6 (95% CI = 1.33–9.58, p = 0.01) times higher than the respective lowest tertiles. The correlation between TTR and blood glucose was statistically significant (r = 0.18, p < 0.05), but not found this relationship in RBP4. Conclusions The associations of RBP4 and TTR with hypertriglyceridemia and insulin resistance may have important implications for the risk of heart disease and stroke. |
| first_indexed | 2024-12-12T09:36:53Z |
| format | Article |
| id | doaj.art-678295bd2cfd43a9a779b61a8ac8f15d |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-12T09:36:53Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-678295bd2cfd43a9a779b61a8ac8f15d2022-12-22T00:28:41ZengBMCBMC Endocrine Disorders1472-68232018-05-011811710.1186/s12902-018-0254-2Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes riskKarunee Kwanbunjan0Pornpimol Panprathip1Chanchira Phosat2Noppanath Chumpathat3Naruemon Wechjakwen4Somchai Puduang5Ratchada Auyyuenyong6Ina Henkel7Florian J. Schweigert8Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol UniversityDepartment of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol UniversityDepartment of Nutrition, Faculty of Public Health, Mahidol UniversityFaculty of Nursing, Huachiew Chalermprakiet UniversityFaculty of Public Health, Nakhonratchasima Rajabhat UniversityDepartment of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol UniversityDepartment of Food Business and Nutrition, Faculty of Agriculture, Ubon Ratchathani Rajabhat UniversityInstitute of Nutritional Science, University of PotsdamInstitute of Nutritional Science, University of PotsdamAbstract Background Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and type 2 diabetes mellitus. The objective of this study was to elucidate the relationship between RBP4, TTR, triglyceride (TG) and type 2 diabetes risk in rural Thailand. Methods We measured the serum RBP4, TTR, glucose, triglyceride and insulin levels, and glucose tolerance of 167 volunteers from Sung Noen District, Nakhon Ratchasima Province, Thailand. Student’s t-test, Pearson’s correlation and logistic regression analysis were used to evaluate the relationships between RBP4, TTR and type 2 diabetes markers. Results RBP4 and TTR levels, as well as homeostatic model assessment of insulin resistance (HOMA-IR) values, were significantly elevated among subjects with high triglyceride levels (p < 0.01, p < 0.05, p < 0.05, respectively). Triglyceride levels correlated with RBP4 (r = 0.34, p < 0.001) and TTR (r = 0.26, p < 0.01) levels, as well as HOMA-IR values (r = 0.16, p < 0.05). After adjustment for age and gender, the risk of hypertriglyceridemia was 3.7 times greater (95% CI =1.42–9.73, p = 0.008) in the highest RBP4 tertile as compared to the lowest tertile. Similarly, the highest TTR and HOMA-IR tertiles had greater risk of hypertriglyceridemia at 3.5 (95% CI = 1.30–9.20, p = 0.01) and 3.6 (95% CI = 1.33–9.58, p = 0.01) times higher than the respective lowest tertiles. The correlation between TTR and blood glucose was statistically significant (r = 0.18, p < 0.05), but not found this relationship in RBP4. Conclusions The associations of RBP4 and TTR with hypertriglyceridemia and insulin resistance may have important implications for the risk of heart disease and stroke.http://link.springer.com/article/10.1186/s12902-018-0254-2RBP4TTRHOMA-IRHypertriglyceridemiaType 2 diabetes |
| spellingShingle | Karunee Kwanbunjan Pornpimol Panprathip Chanchira Phosat Noppanath Chumpathat Naruemon Wechjakwen Somchai Puduang Ratchada Auyyuenyong Ina Henkel Florian J. Schweigert Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk BMC Endocrine Disorders RBP4 TTR HOMA-IR Hypertriglyceridemia Type 2 diabetes |
| title | Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk |
| title_full | Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk |
| title_fullStr | Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk |
| title_full_unstemmed | Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk |
| title_short | Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk |
| title_sort | association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk |
| topic | RBP4 TTR HOMA-IR Hypertriglyceridemia Type 2 diabetes |
| url | http://link.springer.com/article/10.1186/s12902-018-0254-2 |
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