Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy
Background. The treatment of peripheral diabetic neuropathy is difficult to treat considering the pain is severe, long-lasting and does not respond to analgesics. Gabapentin has been recommended as the first line treatment for DPN but owing to cognitive dysfunction and other side effects the drug is...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2022-09-01
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| Series: | Romanian Journal of Neurology |
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| Online Access: | https://rjn.com.ro/articles/2022.3/RJN_2022_3_Art-08.pdf |
| _version_ | 1797946631152205824 |
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| author | Wadha Nawal Zaffer Faiz Unnisa Farath Unnisa Ayesha Tahoora Fatima Azmath Unnisa Begum1 Mohammed Zoheb |
| author_facet | Wadha Nawal Zaffer Faiz Unnisa Farath Unnisa Ayesha Tahoora Fatima Azmath Unnisa Begum1 Mohammed Zoheb |
| author_sort | Wadha Nawal Zaffer |
| collection | DOAJ |
| description | Background. The treatment of peripheral diabetic neuropathy is difficult to treat considering the pain is severe, long-lasting and does not respond to analgesics. Gabapentin has been recommended as the first line treatment for DPN but owing to cognitive dysfunction and other side effects the drug is discontinued. Recent studies suggest that oxcarbazepine; an antiepileptic drug has good-efficacy in management of DPN. This prospective, observational and comparative study was done to compare gabapentin and oxcarbazepine monotherapy in patient of DPN. Objectives. We assessed the efficacy of Oxcarbazepine monotherapy in terms of pain score, sleep score and quality of life and compared with gabapentin monotherapy. Methods. 100 patients with DPN or examinations suggesting DPN were divided into 2 groups to receive gabapentin 300- 1200 mg/day or Oxcarbazepine 300-600mg/day. Assessment of pain scores, sleep score and quality of life were done at different duration during the course of therapy. Results. Out of total subject selected, the maximum (46%) subjects were between age group 60-90 years and the least effected were (24%) between age group 50-59 years. Male were more prevalent with 57% when compared to females with 43%. Improvement in Sleep was seen on using Group II with p value (0.0005). However, the correlation of Pain and Quality of life with the treatment shows p –value 0.24, 0.31 and 0.27 respectively showing non-significance. Conclusion. The sleep improved statistically correlated in patients with DPN, but not with quality of life and pain as the calculated p value was (p= 0.24, 0.31 and 0.27) respectively. Findings of this study suggest that oxcarbazepine can be used as an alternative treatment owing to its similar analgesic efficacy and improvement in sleep. |
| first_indexed | 2024-04-10T21:14:10Z |
| format | Article |
| id | doaj.art-6783c59564434be3ab1e85be7c21ca50 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-10T21:14:10Z |
| publishDate | 2022-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-6783c59564434be3ab1e85be7c21ca502023-01-20T12:48:28ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942022-09-0121324224710.37897/RJN.2022.3.8Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathyWadha Nawal Zaffer0Faiz Unnisa1Farath Unnisa2Ayesha Tahoora Fatima3Azmath Unnisa Begum14Mohammed Zoheb5Department of Pharmacy practice, Deccan School of Pharmacy, IndiaDepartment of Pharmacy practice, Deccan School of Pharmacy, IndiaDepartment of Pharmacy practice, Deccan School of Pharmacy, IndiaDepartment of Pharmacy practice, Deccan School of Pharmacy, IndiaDepartment of Pharmacy practice, Deccan School of Pharmacy, IndiaDepartment of Neurology, Owaisi Hospital and Research Centre, Deccan College of Medical Sciences, IndiaBackground. The treatment of peripheral diabetic neuropathy is difficult to treat considering the pain is severe, long-lasting and does not respond to analgesics. Gabapentin has been recommended as the first line treatment for DPN but owing to cognitive dysfunction and other side effects the drug is discontinued. Recent studies suggest that oxcarbazepine; an antiepileptic drug has good-efficacy in management of DPN. This prospective, observational and comparative study was done to compare gabapentin and oxcarbazepine monotherapy in patient of DPN. Objectives. We assessed the efficacy of Oxcarbazepine monotherapy in terms of pain score, sleep score and quality of life and compared with gabapentin monotherapy. Methods. 100 patients with DPN or examinations suggesting DPN were divided into 2 groups to receive gabapentin 300- 1200 mg/day or Oxcarbazepine 300-600mg/day. Assessment of pain scores, sleep score and quality of life were done at different duration during the course of therapy. Results. Out of total subject selected, the maximum (46%) subjects were between age group 60-90 years and the least effected were (24%) between age group 50-59 years. Male were more prevalent with 57% when compared to females with 43%. Improvement in Sleep was seen on using Group II with p value (0.0005). However, the correlation of Pain and Quality of life with the treatment shows p –value 0.24, 0.31 and 0.27 respectively showing non-significance. Conclusion. The sleep improved statistically correlated in patients with DPN, but not with quality of life and pain as the calculated p value was (p= 0.24, 0.31 and 0.27) respectively. Findings of this study suggest that oxcarbazepine can be used as an alternative treatment owing to its similar analgesic efficacy and improvement in sleep.https://rjn.com.ro/articles/2022.3/RJN_2022_3_Art-08.pdfdiabetic peripheral neuropathygabapentinoxcarbazepinesleep scorepain scorequality of life |
| spellingShingle | Wadha Nawal Zaffer Faiz Unnisa Farath Unnisa Ayesha Tahoora Fatima Azmath Unnisa Begum1 Mohammed Zoheb Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy Romanian Journal of Neurology diabetic peripheral neuropathy gabapentin oxcarbazepine sleep score pain score quality of life |
| title | Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy |
| title_full | Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy |
| title_fullStr | Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy |
| title_full_unstemmed | Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy |
| title_short | Efficacy of Gabapentin vs Oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy |
| title_sort | efficacy of gabapentin vs oxcarbazepine in terms of pain sleep and quality of life in patients with diabetic peripheral neuropathy |
| topic | diabetic peripheral neuropathy gabapentin oxcarbazepine sleep score pain score quality of life |
| url | https://rjn.com.ro/articles/2022.3/RJN_2022_3_Art-08.pdf |
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