CD44 Expression Profile Varies According to Maturational Subtypes and Molecular Profiles of Pediatric T-Cell Lymphoblastic Leukemia

CD44 Expression Profile Varies According to Maturational Subtypes and Molecular Profiles of Pediatric T-Cell Lymphoblastic Leukemia

CD44 is a glycoprotein expressed in leucocytes and a marker of leukemia-initiating cells, being shown to be important in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). In this study, we have (i) identified the aberrant antigenic pattern of CD44 and its isoform CD44v6 in T-ALL; (ii)...

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Main Authors: Luísa Vieira Codeço Marques, Elda Pereira Noronha, Francianne Gomes Andrade, Filipe Vicente dos Santos-Bueno, Marcela B. Mansur, Eugenia Terra-Granado, Maria S. Pombo-de-Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
CD44
CD44/CD44v6
T-cell leukemia
acute myeloid leukemia
NOTCH1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00488/full

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