Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination

Abstract Background Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, which potentially allow for the gradual adaptation and maturation of haplot...

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Bibliographic Details
Main Authors: Bernett Lee, Samantha Leeanne Cyrill, Wendy Lee, Rossella Melchiotti, Anand Kumar Andiappan, Michael Poidinger, Olaf Rötzschke
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Biology
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Online Access:https://doi.org/10.1186/s12915-022-01353-9