Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases
Transient potential receptor vanilloid 4(TRPV4)is a cluster of non-selective cation channels presented on cell membranes. They are important mediators of sensory signals that regulate cell function and signaling pathways. TRPV4 is widely expressed in various ocular tissues and can participate in a v...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2023-01-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/1/202301009.pdf |
| _version_ | 1797962206820696064 |
|---|---|
| author | Feng Wang Jiang-Feng Lai Ling-Ying Cao Yi Shao |
| author_facet | Feng Wang Jiang-Feng Lai Ling-Ying Cao Yi Shao |
| author_sort | Feng Wang |
| collection | DOAJ |
| description | Transient potential receptor vanilloid 4(TRPV4)is a cluster of non-selective cation channels presented on cell membranes. They are important mediators of sensory signals that regulate cell function and signaling pathways. TRPV4 is widely expressed in various ocular tissues and can participate in a variety of physiological functions, including osmotic pressure regulation, Ca2+ homeostasis, apoptosis and autophagy. It plays an important role in normal physiological functions and different pathology. Recent studies have revealed that TRPV4 is closely correlated to corneal epithelial injury, glaucoma, age-related cataract, diabetic retinopathy, retinopathy of prematurity, retinal detachment and other diseases. Besides, studies also showed that TRPV4 regulates the occurrence and development of its related ophthalmic diseases. This paper briefly reviewed the research progress on TRPV4 pathway in ophthalmic diseases, so as to provide ideas for the clinical treatment of ophthalmopathy. |
| first_indexed | 2024-04-11T01:09:44Z |
| format | Article |
| id | doaj.art-67890c759ae645ddb5363d8425dd53b0 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-11T01:09:44Z |
| publishDate | 2023-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-67890c759ae645ddb5363d8425dd53b02023-01-04T07:41:52ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-01-01231485210.3980/j.issn.1672-5123.2023.1.09202301009Research progress of transient potential receptor vanilloid 4 in ophthalmic diseasesFeng Wang0Jiang-Feng Lai1Ling-Ying Cao2Yi Shao3Department of Ophthalmology, Meizhou Pepole's Hospital, Meizhou 514000, Guangdong Province, ChinaDepartment of Ophthalmology, Meizhou Pepole's Hospital, Meizhou 514000, Guangdong Province, ChinaDepartment of Ophthalmology, Meizhou Pepole's Hospital, Meizhou 514000, Guangdong Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaTransient potential receptor vanilloid 4(TRPV4)is a cluster of non-selective cation channels presented on cell membranes. They are important mediators of sensory signals that regulate cell function and signaling pathways. TRPV4 is widely expressed in various ocular tissues and can participate in a variety of physiological functions, including osmotic pressure regulation, Ca2+ homeostasis, apoptosis and autophagy. It plays an important role in normal physiological functions and different pathology. Recent studies have revealed that TRPV4 is closely correlated to corneal epithelial injury, glaucoma, age-related cataract, diabetic retinopathy, retinopathy of prematurity, retinal detachment and other diseases. Besides, studies also showed that TRPV4 regulates the occurrence and development of its related ophthalmic diseases. This paper briefly reviewed the research progress on TRPV4 pathway in ophthalmic diseases, so as to provide ideas for the clinical treatment of ophthalmopathy.http://ies.ijo.cn/cn_publish/2023/1/202301009.pdftransient potential receptor vanilloid 4(trpv4)corneal epithelial injuryglaucomaage-related cataractretina |
| spellingShingle | Feng Wang Jiang-Feng Lai Ling-Ying Cao Yi Shao Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases Guoji Yanke Zazhi transient potential receptor vanilloid 4(trpv4) corneal epithelial injury glaucoma age-related cataract retina |
| title | Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases |
| title_full | Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases |
| title_fullStr | Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases |
| title_full_unstemmed | Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases |
| title_short | Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases |
| title_sort | research progress of transient potential receptor vanilloid 4 in ophthalmic diseases |
| topic | transient potential receptor vanilloid 4(trpv4) corneal epithelial injury glaucoma age-related cataract retina |
| url | http://ies.ijo.cn/cn_publish/2023/1/202301009.pdf |
| work_keys_str_mv | AT fengwang researchprogressoftransientpotentialreceptorvanilloid4inophthalmicdiseases AT jiangfenglai researchprogressoftransientpotentialreceptorvanilloid4inophthalmicdiseases AT lingyingcao researchprogressoftransientpotentialreceptorvanilloid4inophthalmicdiseases AT yishao researchprogressoftransientpotentialreceptorvanilloid4inophthalmicdiseases |