To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer
Background: Chronic non-healing ulcers (NHUs) are often associated with some underlying pathology which prevents timely healing thus increasing the patients morbidity and healthcare expenses. Autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting also known as Jodhpur technique...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Cutaneous and Aesthetic Surgery |
| Subjects: | |
| Online Access: | http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=1;spage=17;epage=23;aulast=Bhansali |
| _version_ | 1811240223989825536 |
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| author | Shreyansh Bhansali Dilip Kachhawa Pankaj Rao |
| author_facet | Shreyansh Bhansali Dilip Kachhawa Pankaj Rao |
| author_sort | Shreyansh Bhansali |
| collection | DOAJ |
| description | Background: Chronic non-healing ulcers (NHUs) are often associated with some underlying pathology which prevents timely healing thus increasing the patients morbidity and healthcare expenses. Autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting also known as Jodhpur technique (JT), an epidermal graft and autologous platelet-rich fibrin matrix (PRFM) are newer modalities with promising results. Aims: To compare the efficacy and safety of JT and autologous PRFM in the treatment of chronic NHU. Design: A prospective hospital based interventional study conducted on 50 patients of chronic NHU attending the dermatology outdoor of a tertiary level government hospital. Materials and Methods: After taking clearance from the institutional ethical committee, the patients were enrolled into 2 groups of 25 each. JT was done on group A and autologous PRFM on group B and their efficacy and safety compared. Statistical Analysis: Chi square test was used to analyze categorical variables summarized as number and percentage while continuous variables were analyzed using student t-test for intergroup comparison. Results: In Group A, the mean time to ulcer healing was 6.17 ± 2.17 weeks while 6.43 ± 2.33 weeks in Group B. No side effects were found in either group. Conclusion: Both the techniques fair equally in terms of wound healing time and safety but required multiple sittings in group B and a single session in group A. |
| first_indexed | 2024-04-12T13:16:34Z |
| format | Article |
| id | doaj.art-678a38b3abc0432ba652260893643792 |
| institution | Directory Open Access Journal |
| issn | 0974-2077 |
| language | English |
| last_indexed | 2024-04-12T13:16:34Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cutaneous and Aesthetic Surgery |
| spelling | doaj.art-678a38b3abc0432ba6522608936437922022-12-22T03:31:41ZengWolters Kluwer Medknow PublicationsJournal of Cutaneous and Aesthetic Surgery0974-20772022-01-01151172310.4103/JCAS.JCAS_196_20To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcerShreyansh BhansaliDilip KachhawaPankaj RaoBackground: Chronic non-healing ulcers (NHUs) are often associated with some underlying pathology which prevents timely healing thus increasing the patients morbidity and healthcare expenses. Autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting also known as Jodhpur technique (JT), an epidermal graft and autologous platelet-rich fibrin matrix (PRFM) are newer modalities with promising results. Aims: To compare the efficacy and safety of JT and autologous PRFM in the treatment of chronic NHU. Design: A prospective hospital based interventional study conducted on 50 patients of chronic NHU attending the dermatology outdoor of a tertiary level government hospital. Materials and Methods: After taking clearance from the institutional ethical committee, the patients were enrolled into 2 groups of 25 each. JT was done on group A and autologous PRFM on group B and their efficacy and safety compared. Statistical Analysis: Chi square test was used to analyze categorical variables summarized as number and percentage while continuous variables were analyzed using student t-test for intergroup comparison. Results: In Group A, the mean time to ulcer healing was 6.17 ± 2.17 weeks while 6.43 ± 2.33 weeks in Group B. No side effects were found in either group. Conclusion: Both the techniques fair equally in terms of wound healing time and safety but required multiple sittings in group B and a single session in group A.http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=1;spage=17;epage=23;aulast=Bhansaliautologous non-cultured non-trypsinized keratinocyte and melanocyte graftingautologous platelet-rich fibrin matrixjodhpur techniquenon-healing ulcer |
| spellingShingle | Shreyansh Bhansali Dilip Kachhawa Pankaj Rao To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer Journal of Cutaneous and Aesthetic Surgery autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting autologous platelet-rich fibrin matrix jodhpur technique non-healing ulcer |
| title | To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer |
| title_full | To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer |
| title_fullStr | To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer |
| title_full_unstemmed | To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer |
| title_short | To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer |
| title_sort | to compare the efficacy and safety of autologous non cultured non trypsinized keratinocyte and melanocyte grafting jodhpur technique with autologous platelet rich fibrin matrix prfm in the treatment of chronic non healing ulcer |
| topic | autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting autologous platelet-rich fibrin matrix jodhpur technique non-healing ulcer |
| url | http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=1;spage=17;epage=23;aulast=Bhansali |
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