Modification of methacrylate bone cement with eugenol – A new material with antibacterial properties
Nowadays, the search for unconventional antibacterial agents is very common. One of them may be eugenol (EU) (4-allyl-2-methoxyphenol), which exhibits antimicrobial properties against pathogenic bacteria and is used in the pharmaceutical industry. Owing to its structure, EU decreases the exotherm of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2024-03-01
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| Series: | Reviews on Advanced Materials Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/rams-2023-0171 |
| _version_ | 1797266147678093312 |
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| author | Przesławski Grzegorz Szcześniak Katarzyna Grześkowiak Bartosz Mazzaglia Antonino Jarzębski Maciej Niewczas Agata Kuczyński Paweł Zarębska-Mróz Aneta Marcinkowska Agnieszka |
| author_facet | Przesławski Grzegorz Szcześniak Katarzyna Grześkowiak Bartosz Mazzaglia Antonino Jarzębski Maciej Niewczas Agata Kuczyński Paweł Zarębska-Mróz Aneta Marcinkowska Agnieszka |
| author_sort | Przesławski Grzegorz |
| collection | DOAJ |
| description | Nowadays, the search for unconventional antibacterial agents is very common. One of them may be eugenol (EU) (4-allyl-2-methoxyphenol), which exhibits antimicrobial properties against pathogenic bacteria and is used in the pharmaceutical industry. Owing to its structure, EU decreases the exotherm of polymerization without a negative impact on the degree of conversion. The properties of EU-modified bone cement, such as doughing time, maximum temperature, and setting time, will be characterized, as well as mechanical properties, EU release, and antibacterial properties. Bone cements were synthesized by mixing a powder phase composed of two commercially available methacrylate copolymers (Evonic) and a liquid phase containing 2-hydroxyethyl methacrylate, methyl methacrylate, triethylene glycol dimethacrylate, and EU with an amount of 0.5 wt% of bone cement sample. As an initiating system, benzoyl peroxide and N,N-dimethylaniline were used. Samples were prepared with various amounts of the initiating system. The doughing time, maximum temperature (T
max), setting temperature (T
set), setting time (t
set), and compressive strength tests were determined according to the ISO 5833:2002 standard requirements. The doughing time for bone cement depends on the amount of the initiating system. The maximum temperature during curing of bone cement is very low; however, the setting time is closer to the upper limit set by the standard. The compressive strength of the tested materials is good and significantly exceeds the requirements of the standard. EU release was very high and ranged from around 43–62% after 168 h. Moreover, antibacterial studies show that the tested bone cements are bacteriostatic for Staphylococcus aureus or and Escherichia coil strains. In summary, modified bone cements meet the ISO 5833:2002 standard requirements in all parameters and are characterized by good mechanical properties (similar to or higher than commercial bone cement), high EU release, and bacteriostatic properties. |
| first_indexed | 2024-04-25T00:56:04Z |
| format | Article |
| id | doaj.art-678a7567265c4add93a32a61c397456c |
| institution | Directory Open Access Journal |
| issn | 1605-8127 |
| language | English |
| last_indexed | 2024-04-25T00:56:04Z |
| publishDate | 2024-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Reviews on Advanced Materials Science |
| spelling | doaj.art-678a7567265c4add93a32a61c397456c2024-03-11T10:05:14ZengDe GruyterReviews on Advanced Materials Science1605-81272024-03-01631pp. 15716310.1515/rams-2023-0171Modification of methacrylate bone cement with eugenol – A new material with antibacterial propertiesPrzesławski Grzegorz0Szcześniak Katarzyna1Grześkowiak Bartosz2Mazzaglia Antonino3Jarzębski Maciej4Niewczas Agata5Kuczyński Paweł6Zarębska-Mróz Aneta7Marcinkowska Agnieszka8Faculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, Poznan, PolandFaculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, Poznan, PolandNanoBioMedical Center, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, Poznan, PolandCNR-ISMN, Istituto per lo Studio dei Materiali Nanostrutturati, URT of Messina c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina, V.le F.Stagno d’Alcontres 31, Messina, ItalyDepartment of Physics and Biophysics, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, Wojska Polskiego 38/42, Poznan, PolandDepartment of Conservative Dentistry with Endodontic, Chodźki 6, Lublin, PolandRehabilitation and Orthopedics Clinic, Faculty of Health Sciences, Medical University of Lublin, Janczewskiego 8, Lublin, PolandRehabilitation and Orthopedics Clinic, Faculty of Health Sciences, Medical University of Lublin, Janczewskiego 8, Lublin, PolandFaculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, Poznan, PolandNowadays, the search for unconventional antibacterial agents is very common. One of them may be eugenol (EU) (4-allyl-2-methoxyphenol), which exhibits antimicrobial properties against pathogenic bacteria and is used in the pharmaceutical industry. Owing to its structure, EU decreases the exotherm of polymerization without a negative impact on the degree of conversion. The properties of EU-modified bone cement, such as doughing time, maximum temperature, and setting time, will be characterized, as well as mechanical properties, EU release, and antibacterial properties. Bone cements were synthesized by mixing a powder phase composed of two commercially available methacrylate copolymers (Evonic) and a liquid phase containing 2-hydroxyethyl methacrylate, methyl methacrylate, triethylene glycol dimethacrylate, and EU with an amount of 0.5 wt% of bone cement sample. As an initiating system, benzoyl peroxide and N,N-dimethylaniline were used. Samples were prepared with various amounts of the initiating system. The doughing time, maximum temperature (T max), setting temperature (T set), setting time (t set), and compressive strength tests were determined according to the ISO 5833:2002 standard requirements. The doughing time for bone cement depends on the amount of the initiating system. The maximum temperature during curing of bone cement is very low; however, the setting time is closer to the upper limit set by the standard. The compressive strength of the tested materials is good and significantly exceeds the requirements of the standard. EU release was very high and ranged from around 43–62% after 168 h. Moreover, antibacterial studies show that the tested bone cements are bacteriostatic for Staphylococcus aureus or and Escherichia coil strains. In summary, modified bone cements meet the ISO 5833:2002 standard requirements in all parameters and are characterized by good mechanical properties (similar to or higher than commercial bone cement), high EU release, and bacteriostatic properties.https://doi.org/10.1515/rams-2023-0171bone cementantibacterial agentseugenoldrug releaseantibacterial properties |
| spellingShingle | Przesławski Grzegorz Szcześniak Katarzyna Grześkowiak Bartosz Mazzaglia Antonino Jarzębski Maciej Niewczas Agata Kuczyński Paweł Zarębska-Mróz Aneta Marcinkowska Agnieszka Modification of methacrylate bone cement with eugenol – A new material with antibacterial properties Reviews on Advanced Materials Science bone cement antibacterial agents eugenol drug release antibacterial properties |
| title | Modification of methacrylate bone cement with eugenol – A new material with antibacterial properties |
| title_full | Modification of methacrylate bone cement with eugenol – A new material with antibacterial properties |
| title_fullStr | Modification of methacrylate bone cement with eugenol – A new material with antibacterial properties |
| title_full_unstemmed | Modification of methacrylate bone cement with eugenol – A new material with antibacterial properties |
| title_short | Modification of methacrylate bone cement with eugenol – A new material with antibacterial properties |
| title_sort | modification of methacrylate bone cement with eugenol a new material with antibacterial properties |
| topic | bone cement antibacterial agents eugenol drug release antibacterial properties |
| url | https://doi.org/10.1515/rams-2023-0171 |
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