A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques

A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques

Background: Persistent transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has given rise to a COVID-19 pandemic. Several vaccines, conceived in 2020, that evoke protective spike antibody responses are being deployed in mass public health vaccination programs. Recent data su...

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Bibliographic Details
Main Authors: Paul E. Harris, Trevor Brasel, Christopher Massey, C. V. Herst, Scott Burkholz, Peter Lloyd, Tikoes Blankenberg, Thomas M. Bey, Richard Carback, Thomas Hodge, Serban Ciotlos, Lu Wang, Jason E. Comer, Reid M. Rubsamen
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Vaccines
Subjects:
SARS-CoV-2
animal model
macaque
vaccine
MHC class I peptide
T cell
Online Access:https://www.mdpi.com/2076-393X/9/5/520

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