Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.
Cytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB)--Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known.To identify the influence of coincident PDM on cytokine levels in PTB...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4230980?pdf=render |
| _version_ | 1828971439260172288 |
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| author | Nathella Pavan Kumar Vaithilingam V Banurekha Dina Nair Rathinam Sridhar Hardy Kornfeld Thomas B Nutman Subash Babu |
| author_facet | Nathella Pavan Kumar Vaithilingam V Banurekha Dina Nair Rathinam Sridhar Hardy Kornfeld Thomas B Nutman Subash Babu |
| author_sort | Nathella Pavan Kumar |
| collection | DOAJ |
| description | Cytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB)--Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known.To identify the influence of coincident PDM on cytokine levels in PTB, we examined circulating levels of a panel of cytokines in the plasma of individuals with TB-PDM and compared them with those without PDM (TB-NDM).TB-PDM is characterized by elevated circulating levels of Type 1 (IFNγ, TNFα and IL-2), Type 17 (IL-17A and IL-17F) and other pro-inflammatory (IL-1β, IFNβ and GM-CSF) cytokines. TB-PDM is also characterized by increased systemic levels of Type 2 (IL-5) and regulatory (IL-10 and TGFβ) cytokines. Moreover, TB antigen stimulated whole blood also showed increased levels of pro-inflammatory (IFNγ, TNFα and IL-1β) cytokines as well. However, the cytokines did not exhibit any significant correlation with HbA1C levels or with bacterial burdens.Our data reveal that pre-diabetes in PTB individuals is characterized by heightened cytokine responsiveness, indicating that a balanced pro and anti - inflammatory cytokine milieu is a feature of pre-diabetes--TB co-morbidity. |
| first_indexed | 2024-12-14T13:09:28Z |
| format | Article |
| id | doaj.art-679198dba2334b009d91f5ddb5934b9d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T13:09:28Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-679198dba2334b009d91f5ddb5934b9d2022-12-21T23:00:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11210810.1371/journal.pone.0112108Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.Nathella Pavan KumarVaithilingam V BanurekhaDina NairRathinam SridharHardy KornfeldThomas B NutmanSubash BabuCytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB)--Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known.To identify the influence of coincident PDM on cytokine levels in PTB, we examined circulating levels of a panel of cytokines in the plasma of individuals with TB-PDM and compared them with those without PDM (TB-NDM).TB-PDM is characterized by elevated circulating levels of Type 1 (IFNγ, TNFα and IL-2), Type 17 (IL-17A and IL-17F) and other pro-inflammatory (IL-1β, IFNβ and GM-CSF) cytokines. TB-PDM is also characterized by increased systemic levels of Type 2 (IL-5) and regulatory (IL-10 and TGFβ) cytokines. Moreover, TB antigen stimulated whole blood also showed increased levels of pro-inflammatory (IFNγ, TNFα and IL-1β) cytokines as well. However, the cytokines did not exhibit any significant correlation with HbA1C levels or with bacterial burdens.Our data reveal that pre-diabetes in PTB individuals is characterized by heightened cytokine responsiveness, indicating that a balanced pro and anti - inflammatory cytokine milieu is a feature of pre-diabetes--TB co-morbidity.http://europepmc.org/articles/PMC4230980?pdf=render |
| spellingShingle | Nathella Pavan Kumar Vaithilingam V Banurekha Dina Nair Rathinam Sridhar Hardy Kornfeld Thomas B Nutman Subash Babu Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis. PLoS ONE |
| title | Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis. |
| title_full | Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis. |
| title_fullStr | Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis. |
| title_full_unstemmed | Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis. |
| title_short | Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis. |
| title_sort | coincident pre diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis |
| url | http://europepmc.org/articles/PMC4230980?pdf=render |
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