The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens
Oxaliplatin (cyclohexane-1,2-diamine; oxalate; platinum [2+]) is a third-generation chemotherapeutic drug with anticancer effects. Oxaliplatin has a role in the treatment of several cancers. It is one of the few drugs which can eliminate the neoplastic cells of colorectal cancer. Also, it has an inf...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-10-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338231206003 |
| _version_ | 1827791271627849728 |
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| author | Ali Tavakoli Pirzaman MD Manijeh Ebrahimzadeh Pirshahid MD Bahareh Babajani MS Amirhossein Rahmati MS Shokat Niknezhad MS Rezvan Hosseinzadeh MD Mehdi Taheri MS Faezeh Ebrahimi-Zadeh MD Shahrbanoo Doostmohamadian MS Sohrab Kazemi PhD |
| author_facet | Ali Tavakoli Pirzaman MD Manijeh Ebrahimzadeh Pirshahid MD Bahareh Babajani MS Amirhossein Rahmati MS Shokat Niknezhad MS Rezvan Hosseinzadeh MD Mehdi Taheri MS Faezeh Ebrahimi-Zadeh MD Shahrbanoo Doostmohamadian MS Sohrab Kazemi PhD |
| author_sort | Ali Tavakoli Pirzaman MD |
| collection | DOAJ |
| description | Oxaliplatin (cyclohexane-1,2-diamine; oxalate; platinum [2+]) is a third-generation chemotherapeutic drug with anticancer effects. Oxaliplatin has a role in the treatment of several cancers. It is one of the few drugs which can eliminate the neoplastic cells of colorectal cancer. Also, it has an influential role in breast cancer, lung cancer, bladder cancer, prostate cancer, and gastric cancer. Although oxaliplatin has many beneficial effects in cancer treatment, resistance to this drug is in the way to cure neoplastic cells and reduce treatment efficacy. microRNAs are a subtype of small noncoding RNAs with ∼22 nucleotides that exist among species. They have diverse roles in physiological processes, including cellular proliferation and cell death. Moreover, miRNAs have essential roles in resistance to cancer treatment and can strengthen sensitivity to chemotherapeutic drugs and regimens. In colorectal cancer, the co-treatment of oxaliplatin with anti-miR-19a can partially reverse the oxaliplatin resistance through the upregulation of phosphatase and tensin homolog (PTEN). Moreover, by preventing the spread of gastric cancer cells and downregulating glypican-3 (GPC3), MiR-4510 may modify immunosuppressive signals in the tumor microenvironment. Treatment with oxaliplatin may develop into a specialized therapeutic drug for patients with miR-4510 inhibition and glypican-3-expressing gastric cancer. Eventually, miR-122 upregulation or Wnt/β-catenin signaling suppression boosted the death of HCC cells and made them more sensitive to oxaliplatin. Herein, we have reviewed the role of microRNAs in regulating cancer cells’ response to oxaliplatin, with particular attention to gastrointestinal cancers. We also discussed the role of these noncoding RNAs in the pathophysiology of oxaliplatin-induced neuropathic pain. |
| first_indexed | 2024-03-11T17:44:51Z |
| format | Article |
| id | doaj.art-679201c6f1db448ba7559bf7d11b7abf |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-03-11T17:44:51Z |
| publishDate | 2023-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-679201c6f1db448ba7559bf7d11b7abf2023-10-18T08:33:25ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382023-10-012210.1177/15330338231206003The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing RegimensAli Tavakoli Pirzaman MD0Manijeh Ebrahimzadeh Pirshahid MD1Bahareh Babajani MS2Amirhossein Rahmati MS3Shokat Niknezhad MS4Rezvan Hosseinzadeh MD5Mehdi Taheri MS6Faezeh Ebrahimi-Zadeh MD7Shahrbanoo Doostmohamadian MS8Sohrab Kazemi PhD9 Student Research Committee, , Babol, Iran Student Research Committee, , Babol, Iran Student Research Committee, , Babol, Iran Student Research Committee, , Babol, Iran Student Research Committee, , Babol, Iran Student Research Committee, , Babol, Iran Student Research Committee, , Babol, Iran Student Research Committee, school of Medicine, , Jahrom, Iran Neonatal and Children's Health Research Center, , Gorgan, Iran Cellular and Molecular Biology Research Center, Health Research Center, Babol University of Medical Sciences, Babol, IranOxaliplatin (cyclohexane-1,2-diamine; oxalate; platinum [2+]) is a third-generation chemotherapeutic drug with anticancer effects. Oxaliplatin has a role in the treatment of several cancers. It is one of the few drugs which can eliminate the neoplastic cells of colorectal cancer. Also, it has an influential role in breast cancer, lung cancer, bladder cancer, prostate cancer, and gastric cancer. Although oxaliplatin has many beneficial effects in cancer treatment, resistance to this drug is in the way to cure neoplastic cells and reduce treatment efficacy. microRNAs are a subtype of small noncoding RNAs with ∼22 nucleotides that exist among species. They have diverse roles in physiological processes, including cellular proliferation and cell death. Moreover, miRNAs have essential roles in resistance to cancer treatment and can strengthen sensitivity to chemotherapeutic drugs and regimens. In colorectal cancer, the co-treatment of oxaliplatin with anti-miR-19a can partially reverse the oxaliplatin resistance through the upregulation of phosphatase and tensin homolog (PTEN). Moreover, by preventing the spread of gastric cancer cells and downregulating glypican-3 (GPC3), MiR-4510 may modify immunosuppressive signals in the tumor microenvironment. Treatment with oxaliplatin may develop into a specialized therapeutic drug for patients with miR-4510 inhibition and glypican-3-expressing gastric cancer. Eventually, miR-122 upregulation or Wnt/β-catenin signaling suppression boosted the death of HCC cells and made them more sensitive to oxaliplatin. Herein, we have reviewed the role of microRNAs in regulating cancer cells’ response to oxaliplatin, with particular attention to gastrointestinal cancers. We also discussed the role of these noncoding RNAs in the pathophysiology of oxaliplatin-induced neuropathic pain.https://doi.org/10.1177/15330338231206003 |
| spellingShingle | Ali Tavakoli Pirzaman MD Manijeh Ebrahimzadeh Pirshahid MD Bahareh Babajani MS Amirhossein Rahmati MS Shokat Niknezhad MS Rezvan Hosseinzadeh MD Mehdi Taheri MS Faezeh Ebrahimi-Zadeh MD Shahrbanoo Doostmohamadian MS Sohrab Kazemi PhD The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens Technology in Cancer Research & Treatment |
| title | The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens |
| title_full | The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens |
| title_fullStr | The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens |
| title_full_unstemmed | The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens |
| title_short | The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens |
| title_sort | role of micrornas in regulating cancer cell response to oxaliplatin containing regimens |
| url | https://doi.org/10.1177/15330338231206003 |
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