Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing
Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2020.1853280 |
| _version_ | 1818438715991654400 |
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| author | QingQing Leng Yue Li XianLun Pang BiQiong Wang ZhouXue Wu Yun Lu Kang Xiong Ling Zhao Ping Zhou ShaoZhi Fu |
| author_facet | QingQing Leng Yue Li XianLun Pang BiQiong Wang ZhouXue Wu Yun Lu Kang Xiong Ling Zhao Ping Zhou ShaoZhi Fu |
| author_sort | QingQing Leng |
| collection | DOAJ |
| description | Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively promote the healing of skin wounds. Sustained drug release from the composite film provides long-term protection and treatment for skin wounds. Both antibacterial property and good histocompatibility of the CPCF were examined by analyzing antibacterial activity and cytotoxicity to validate its applicability for wound management. Moreover, in vivo studies proved that the CPCF had a rapid healing rate of 98.03%±0.79% and mature epithelialization on day 15 after surgery. Obvious hair follicles and earlier re-epithelialization was also noticed in the CPCF group using H&E staining. The result of Masson’s trichrome staining confirmed that CPCF could promote the formation of collagen fibers. In summary, CPCF may be promising as a wound dressing agent in wound management owing to its rapid wound-healing effects. |
| first_indexed | 2024-12-14T17:44:59Z |
| format | Article |
| id | doaj.art-6794744f43c6427b9b977ac172792a87 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-14T17:44:59Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-6794744f43c6427b9b977ac172792a872022-12-21T22:52:45ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642020-01-012711676168510.1080/10717544.2020.18532801853280Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healingQingQing Leng0Yue Li1XianLun Pang2BiQiong Wang3ZhouXue Wu4Yun Lu5Kang Xiong6Ling Zhao7Ping Zhou8ShaoZhi Fu9Department of Oncology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversityHealth Management Center, Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Pharmaceutics, School of Pharmacy of Southwest Medical UniversityDepartment of Radiology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversitySkin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively promote the healing of skin wounds. Sustained drug release from the composite film provides long-term protection and treatment for skin wounds. Both antibacterial property and good histocompatibility of the CPCF were examined by analyzing antibacterial activity and cytotoxicity to validate its applicability for wound management. Moreover, in vivo studies proved that the CPCF had a rapid healing rate of 98.03%±0.79% and mature epithelialization on day 15 after surgery. Obvious hair follicles and earlier re-epithelialization was also noticed in the CPCF group using H&E staining. The result of Masson’s trichrome staining confirmed that CPCF could promote the formation of collagen fibers. In summary, CPCF may be promising as a wound dressing agent in wound management owing to its rapid wound-healing effects.http://dx.doi.org/10.1080/10717544.2020.1853280curcuminnanoparticlescollagenpvacomposite filmwound healing |
| spellingShingle | QingQing Leng Yue Li XianLun Pang BiQiong Wang ZhouXue Wu Yun Lu Kang Xiong Ling Zhao Ping Zhou ShaoZhi Fu Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing Drug Delivery curcumin nanoparticles collagen pva composite film wound healing |
| title | Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing |
| title_full | Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing |
| title_fullStr | Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing |
| title_full_unstemmed | Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing |
| title_short | Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing |
| title_sort | curcumin nanoparticles incorporated in pva collagen composite films promote wound healing |
| topic | curcumin nanoparticles collagen pva composite film wound healing |
| url | http://dx.doi.org/10.1080/10717544.2020.1853280 |
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