Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells

Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells

In chronic myelogenous leukemia (CML), treatment with tyrosine kinase inhibitors (TKI) is unable to eradicate leukemic stem cells (LSC). Polymethine dye-functionalized nanoparticles can be internalized by specific cell types using transmembrane carrier proteins. In this study we investigated the upt...

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Bibliographic Details
Main Authors: Philipp Ernst, Adrian T. Press, Mike Fischer, Vivien Günther, Christine Gräfe, Joachim H. Clement, Thomas Ernst, Ulrich S. Schubert, Jana Wotschadlo, Marc Lehmann, Christoph Enzensperger, Michael Bauer, Andreas Hochhaus
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
polymethine dyes
nanoparticles
CML
OATP1B3
OCT1
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052030111X

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