Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase

Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase

<p>Abstract</p> <p>Background</p> <p>HIV-1 nucleoside reverse transcriptase inhibitors (NRTIs) have been used in the clinic for over twenty years. Interestingly, the complete resistance pattern to this class has not been fully elucidated. Novel mutations in RT appearing...

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Bibliographic Details
Main Authors: Kagan Ron M, de Graaf Loek, van Ham Petronella M, Huigen Marleen CDG, Boucher Charles AB, Nijhuis Monique
Format: Article
Language:English
Published: BMC 2008-02-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/5/1/20

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